Website of the Statistical Genetics Group
High-throughput technologies have opened new perspectives to unravel the genetic cause of various diseases or physiological traits, such as body mass index (BMI). Genome-wide association studies (GWAS) measure the correlation …
Parental origin of the genetic code matters for obesity Read MoreWe are interested in how genotypic variability impacts molecular phenotypes and how, together with the environment, this affects complex human traits and disease susceptibility. Our focal molecular phenotype involves the …
Metabolome Genetics Read MoreThe group has become member of the Swiss Institute of Bioinformatics (SIB) after the voting of the SIB Foundation Council on 26 June. Further details are here.
SGG joins SIB Read MoreIn April 2013 Zoltán Kutalik was nominated as Assistant Professor of the Faculty of Biology and Medicine of the University of Lausanne. He will be working in the Statistics Unit …
Zoltán nominated as Assistant Professor Read MoreThe team of Pierre-Yves Bochud (CHUV-UNIL), Zoltán Kutalik (UNIL-SIB), Oscar Marchetti (CHUV-UNIL) and Christian van Delden (HUG & UNIGE) received the Leenaards Prize 2013 for their project “Host genome and …
Leenaards prize 2013 Read MoreThere are many known examples of the allelic heterogeneity and imperfect tagging phenomena. The former one is of great importance in monogenic traits but has not yet been systematically investigated …
Multi-SNP association method reveals allelic heterogeneity Read MoreOnly a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We studied well-characterized HCV-infected patients of European descent …
Two novel SNPs associated with HCV-induced fibrosis progression Read MoreThe HYPERGENES Project investigated associations between genetic variants and essential hypertension pursuing a 2-stage study by recruiting cases and controls from extensively characterized cohorts recruited over many years in different …
Hypergenes eNOS discovery Read MoreUnderweight and obese phenotypes can both pose health risks. But whereas obesity has been associated with a number of genetic variants, little is known about the genetic basis of underweight. …
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus Read MoreGenome-wide association studies (GWAS) are conducted with the promise to discover novel genetic variants associated with diverse traits. For most traits, associated markers individually explain just a modest fraction of …
Novel method to estimate explained variance of GWAS hits reveals large fraction of the missing heritability Read More