Website of the Statistical Genetics Group
There are many known examples of the allelic heterogeneity and imperfect tagging phenomena. The former one is of great importance in monogenic traits but has not yet been systematically investigated …
Multi-SNP association method reveals allelic heterogeneity Read MoreOnly a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We studied well-characterized HCV-infected patients of European descent …
Two novel SNPs associated with HCV-induced fibrosis progression Read MoreThe HYPERGENES Project investigated associations between genetic variants and essential hypertension pursuing a 2-stage study by recruiting cases and controls from extensively characterized cohorts recruited over many years in different …
Hypergenes eNOS discovery Read MoreUnderweight and obese phenotypes can both pose health risks. But whereas obesity has been associated with a number of genetic variants, little is known about the genetic basis of underweight. …
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus Read MoreGenome-wide association studies (GWAS) are conducted with the promise to discover novel genetic variants associated with diverse traits. For most traits, associated markers individually explain just a modest fraction of …
Novel method to estimate explained variance of GWAS hits reveals large fraction of the missing heritability Read MoreVia the CoLaus and Hypergenes cohorts our group contributed to the meta-analysis of the GIANT consortium that revealed hundreds of genetic variants associated with human height; 18 new loci for …
Hundreds of genomic variants are associated with human anthropometric traits Read MoreWe are involved in a Genome-wide Association Study on narcolepsy conducted by Mehdi Tafti’s Group at the University of Lausanne. In brief, we identified a haplotype in the HLA-region that …
Genome-wide Association Study reveals new HLA-haplotype strongly protective against narcolepsy Read More