2021

[17] Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics. Darrous L*, Mounier N*, Kutalik Z. Nat Commun. 2021 Dec 14;12(1):7274. 

[16] The power of genetic diversity in genome-wide association studies of lipids. Graham SE et al. Nature. 2021 Dec 9. doi: 10.1038/s41586-021-04064-3.

[15] Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits. Patxot M, Banos DT, Kousathanas A, Orliac EJ, Ojavee SE, Moser G, Holloway A, Sidorenko J, Kutalik Z, Mägi R, Visscher PM, Rönnegård L, Robinson MR. Nat Commun. 2021 Nov 30;12(1):6972.

[14] Untargeted Metabolome- and Transcriptome-Wide Association Study Suggests Causal Genes Modulating Metabolite Concentrations in Urine. Sönmez Flitman R, Khalili B, Kutalik Z, Rueedi R, Brümmer A, Bergmann S. J Proteome Res. 2021 Oct 26. doi: 10.1021/acs.jproteome.1c00585.

[13] Mendelian randomization to assess causality between uromodulin, blood pressure and chronic kidney disease. Ponte B*, Sadler MC*, Olinger E, Vollenweider P, Bochud M, Padmanabhan S, Hayward C*, Kutalik Z*, Devuyst O*. Kidney Int. 2021 Oct 9:S0085-2538(21)00922-4.

[12] Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome. Porcu E, Sadler MC, Lepik K, Auwerx C, Wood AR, Weihs A, Sleiman MSB, Ribeiro DM, Bandinelli S, Tanaka T, Nauck M, Völker U, Delaneau O, Metspalu A, Teumer A, Frayling T, Santoni FA, Reymond A*, Kutalik Z* Nat Commun. 2021 Sep 24;12(1):5647.

[11] Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape. Sulc J, Sonrel A, Mounier N, Auwerx C, Marouli E, Darrous L, Draganski B, Kilpeläinen TO, Joshi P, Loos RJF, Kutalik Z. Nat Commun Biol. 2021 Sep 13;4(1):1064.

[10] Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Võsa U et al. Nat Genet. 2021 Sep;53(9):1300-1310.

[9] Genetic insights into biological mechanisms governing human ovarian ageing. Ruth KS et al. Nature. 2021 Aug 4. doi: 10.1038/s41586-021-03779-7.

[8] HSD17B7 gene in self-renewal and oncogenicity of keratinocytes from Black versus White populations. Xu X, Tassone B, Ostano P, Katarkar A, Proust T, Joseph JM, Riganti C, Chiorino G, Kutalik Z, Lefort K, Dotto GP. EMBO Mol Med. 2021 Jul 7;13(7):e14133.

[7] Socio-economic position as a moderator of cardiometabolic outcomes in patients receiving psychotropic treatment associated with weight gain: results from a prospective 12-month inception cohort study and a large population-based cohort. Dubath C, Gholam-Rezaee M, Sjaarda J, Levier A, Saigi-Morgui N, Delacrétaz A, Glatard A, Panczak R, Correll CU, Solida A, Plessen KJ, von Gunten A, Kutalik Z, Conus P, Eap CB. Transl Psychiatry. 2021 Jun 26;11(1):360. 

[6] The trans-ancestral genomic architecture of glycemic traits. Chen J et al. Nat Genet. 2021 Jun;53(6):840-860.

[5] Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis. Ojavee SE, Kousathanas A, Trejo Banos D, Orliac EJ, Patxot M, Läll K, Mägi R, Fischer K, Kutalik Z, Robinson MR. Nat Commun. 2021 Apr 20;12(1):2337. 

[4] Triangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes. Porcu E, Gilardi F, Darrous L, Yengo L, Bararpour N, Gasser M, Marques-Vidal P, Froguel P, Waeber G, Thomas A, Kutalik Z. Sci Rep. 2021 Mar 18;11(1):6197.

[3] Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies. Carmeli C, Kutalik Z, Mishra PP, Porcu E, Delpierre C, Delaneau O, Kelly-Irving M, Bochud M, Dhayat NA, Ponte B, Pruijm M, Ehret G, Kähönen M, Lehtimäki T, Raitakari OT, Vineis P, Kivimäki M, Chadeau-Hyam M, Dermitzakis E, Vuilleumier N, Stringhini S. Sci Rep. 2021 Feb 4;11(1):3100.

[1] Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci. Ahluwalia TS et al. Hum Mol Genet. 2021 Jan 30:ddab023. doi: 10.1093/hmg/ddab023. Online ahead of prin