…and it’s a feedforward loop! Qian’s discovery of a nontranscriptional incoherent feedforward loop in a receptor kinase signaling pathway has now been published in the Proceedings of the National Academy of Sciences, U.S.A. Starting from proteomics experiments performed by former postdoc Yeon Hee Kang, we found that the enigmatic MAKR5 protein is an amplifier of CLE45-BAM3 signaling whose abundance is itself regulated via CLE45-BAM3-dependent MAKR5 mRNA translation in a, well, incoherent feedforward loop.
Something’s incoherent here
