(Peer-reviewed) Publications of our work


79. Alice S. Breda, Ora Hazak, Patrick Schultz, Pauline Anne, Moritz Graeff, Rüdiger Simon and Christian S. Hardtke (2019): A cellular insulator against CLE45 peptide signaling. Current Biology, Vol. 29: pp. 2501-2508.


78. Alja van der Schuren, Cătălin Voiniciuc, Jennifer Bragg, Karin Ljung, John Vogel, Markus Pauly and Christian S. Hardtke (2018): Broad spectrum developmental role of Brachypodium AUX1. New Phytologist, Vol. 219: pp. 1216-1223.

77. Petra Marhava, A. E. Lanassa Bassukas, Melina Zourelidou, Martina Kolb, Bernard Moret, Astrid Fastner, Waltraud X. Schulze, Pietro Cattaneo, Ulrich Z. Hammes, Claus Schwechheimer* and Christian S. Hardtke* (2018): A molecular rheostat adjusts auxin flux to promote root protophloem differentiation. Nature, Vol. 558: pp. 297-300.

76. Pauline Anne, Amelia Amiguet-Vercher, Benjamin Brandt, Lothar Kalmbach, Niko Geldner, Michael Hothorn and Christian S. Hardtke (2018): CLERK is a novel receptor kinase required for sensing of root-active CLE peptides in Arabidopsis. Development, Vol. 145: pp. dev.162354.

75. Pauline Anne and Christian S. Hardtke (2018): Phloem function and development — biophysics meets genetics. Current Opinion in Plant Biology, Vol. 43: pp. 22-28.


74. Emanuel Schmid-Siegert, Namrata Sarkar, Christian Iseli, Sandra Calderon, Caroline Gouhier-Darimont, Jacqueline Chrast, Pietro Cattaneo, Frédéric Schütz, Laurent Farinelli, Marco Pagni, Michel Schneider, Jérémie Voumard, Michel Jaboyedoff, Christian Fankhauser*, Christian S. Hardtke*, Laurent Keller*, John R. Pannell*, Alexandre Reymond*, Marc Robinson-Rechavi*, Ioannis Xenarios* and Philippe Reymond* (2017): Low number of fixed somatic mutations in a long-lived oak tree. Nature Plants, Vol. 3: pp. 926-929.

73. Christian S. Hardtke and Yoshiko Takahashi (2017): Editorial overview: Developmental mechanisms, patterning and evolution: Developmental patterning: from stochasticity to plasticity. Current Opinion in Genetics & Development, Vol. 45, pp. iv-v.

72. Saeko Kitakura, Maciek Adamowski, Yuki Matsuura, Luca Santuari, Hirotaka Kouno, Kohei Arima, Christian S. Hardtke, Jiří Friml, Tatsuo Kakimoto and Hirokazu Tanaka (2017): BEN3/BIG2 ARF GEF is Involved in Brefeldin A-sensitive Trafficking at the trans-Golgi Network / Early Endosome in Arabidopsis thaliana. Plant and Cell Physiology, Vol. 58: pp. 1801-1811

71. Pietro Cattaneo and Christian S. Hardtke (2017): BIG BROTHER uncouples cell proliferation from elongation in the Arabidopsis primary root. Plant and Cell Physiology, Vol. 58: pp. 1519-1527

70. Alice S. Breda, Ora Hazak and Christian S. Hardtke (2017): Phosphosite charge rather than shootward localization determines OCTOPUS activity in root protophloem. Proceedings of the National Academy of Sciences U.S.A., Vol. 114: pp. E5721E5730.

69. Ora Hazak, Benjamin Brandt, Pietro Cattaneo, Julia Santiago, Antia Rodriguez-Villalon, Michael Hothorn* and Christian S. Hardtke* (2017): Perception of root-active CLE peptides requires CORYNE function in the phloem vasculature. EMBO Reports, Vol. 18: pp. 1367-1381.

68. Dieuwertje Van der Does, Freddy Boutrot, Timo Engelsdorf, Jack Rhodes, Joseph F. McKenna, Samantha Vernhettes, Iko Koevoets, Nico Tintor, Manikandan Veerabagu, Eva Miedes, Cécile Segonzac, Milena Roux, Alice S. Breda, Christian S. Hardtke, Antonio Molina, Martijn Rep, Christa Testerink, Grégory Mouille, Herman Höfte, Thorsten Hamann and Cyril Zipfel (2017): The Arabidopsis leucine-rich repeat receptor kinase MIK2/LRR-KISS connects cell wall integrity sensing, root growth and response to abiotic and biotic stresses. PLoS Genetics, Vol. 13: pp. e1006832

67. Yeon Hee Kang, Alice S. Breda and Christian S. Hardtke (2017): Brassinosteroid signaling directs formative cell divisions and protophloem differentiation in Arabidopsis root meristems. Development, Vol. 144: pp. 272-280.


66. Julien Alassimone, Satoshi Fujita, Verónica G. Doblas, Maritza van Dop, Marie Barberon, Lothar Kalmbach, Joop E. M. Vermeer, Nelson Rojas-Murcia, Luca Santuari, Christian S. Hardtke and Niko Geldner (2016): Polarly localized kinase SGN1 is required for Casparian strip integrity and positioning. Nature Plants, Vol. 2: pp. 16113.

65. Yeon Hee Kang and Christian S. Hardtke (2016): Arabidopsis MAKR5 is a positive effector of BAM3-dependent CLE45 signaling. EMBO Reports, Vol. 17: pp. 1145-1154.

64. David Pacheco-Villalobos, Sara M. Díaz-Moreno, Alja van der Schuren, Takayuki Tamaki, Yeon Hee Kang, Bojan Gujas, Ondrej Novak, Nina Jaspert, Zhenni Li, Sebastian Wolf, Claudia Oecking, Karin Ljung, Vincent Bulone, and Christian S. Hardtke (2016): The Effects of High Steady State Auxin Levels on Root Cell Elongation in Brachypodium. The Plant Cell, Vol. 28: pp. 1009-1024.

63. Ora Hazak and Christian S. Hardtke (2016): CLAVATA1-Type Receptors in Plant Development. Journal of Experimental Botany, Vol. 67: pp. 4827-4833.

62. Fabio Lehmann and Christian S. Hardtke (2016): Secondary growth of the Arabidopsis hypocotyl — vascular development in 4 dimensions. Current Opinion in Plant Biology, Vol. 29: pp. 9-15.


61. Christian S. Hardtke and David Pacheco-Villalobos (2015): The Brachypodium distachyon root system – a tractable model to investigate grass roots. in Genetics and Genomics of Brachypodium, Springer, 2015.

60. Nathan Czyzewicz, Mari Wildhagen, Pietro Cattaneo, Yvonne Stahl, Karine Gustavo Pinto, Reidunn B. Aalen, Melinka A. Butenko, Rudiger Simon, Christian S. Hardtke and Ive De Smet (2015): Antagonistic peptide technology for functional dissection of CLE peptides revisited. Journal of Experimental Botany, Vol. 66: pp. 5367-5374.

59. Stefano D’Alessandro, Serena Golin, Christian S. Hardtke, Fiorella Lo Schiavo and Michela Zottini (2015): The co-chaperone p23 controls root development through the modulation of auxin distribution in the Arabidopsis root meristem. Journal of Experimental Botany, Vol. 66: pp. 5113-5122.

58. Antia Rodriguez-Villalon, Bojan Gujas, Ringo van Wijk, Teun Munnik and Christian S. Hardtke (2015): Primary root protophloem differentiation requires balanced phosphatidylinositol-4,5-biphosphate levels and systemically affects root branching. Development, Vol. 142: pp. 1437-1446.

57. Amélia Amiguet-Vercher, Luca Santuari, Miguel Gonzalez-Guzman, Stephen Depuydt, Pedro L. Rodriguez and Christian S. Hardtke (2015): The IBO germination QTL encodes a phosphatase 2C-related variant with a non-synonymous amino acid change that interferes with abscisic acid signaling. New Phytologist, Vol. 205: pp. 1076-1082.


56. Antia Rodriguez-Villalon, Bojan Gujas, Yeon Hee Kang, Alice S. Breda, Pietro Cattaneo, Stephen Depuydt and Christian S. Hardtke (2014): Molecular Genetic Framework For Protophloem Formation. Proceedings of the National Academy of Sciences U.S.A., Vol. 111: pp. 11551-11556.

55. Florian Chevalier, Kaisa Nieminen, Juan Carlos Sánchez-Ferrero, María Luisa Rodríguez, Mónica Chagoyen, Christian S. Hardtke and Pilar Cubas (2014): Strigolactone Promotes Degradation of DWARF14, an α/β Hydrolase Essential for Strigolactone Signaling in Arabidopsis. The Plant Cell, Vol. 26: pp. 1134-1150.

54. Martial Sankar, Kaisa Nieminen, Laura Ragni, Ioannis Xenarios and Christian S. Hardtke (2014): Automated quantitative histology reveals vascular morphodynamics during Arabidopsis hypocotyl secondary growth. eLife,

the code for the Automated Quantitative Histology approach can be found here.

53. Antia Rodriguez-Villalon and Christian S. Hardtke (2014): Auxin and its henchmen: hormonal crosstalk in root growth and development. in Auxin and its Role in Plant Development, Springer, 2014.


52. Laura Ragni and Christian S. Hardtke (2013): Small but thick enough – the Arabidopsis hypocotyl as a model to study secondary growth. Physiologia Plantarum, Vol. 151: pp. 164-171.

51. David B. Lowry, Tierney L. Logan, Luca Santuari, Christian S. Hardtke, James H. Richards, Leah J. DeRose-Wilson, John K. McKay, Saunak Sen, and Thomas E. Juenger (2013): Expression Quantitative Trait Locus Mapping across Water Availability Environments Reveals Contrasting Associations with Genomic Features in Arabidopsis. The Plant Cell, Vol. 25: pp. 3266-3279.

50. David Pacheco-Villalobos, Martial Sankar, Karin Ljung and Christian S. Hardtke (2013): Disturbed local auxin homeostasis enhances cellular anisotropy and reveals alternative wiring of auxin-ethylene crosstalk in Brachypodium distachyon seminal roots. PLoS Genetics, Vol. 9: e1003564.

49. Stephen Depuydt, Antia Rodriguez-Villalon, Luca Santuari, Céline Wyser-Rmili, Laura Ragni and Christian S. Hardtke (2013): Suppression of protophloem differentiation and root meristem growth in Arabidopsis by CLE45 requires the receptor-like kinase BAM3. Proceedings of the National Academy of Sciences U.S.A., Vol. 110: pp. 7074-7079.


48. Konstantin Tomanov, Christian S. Hardtke, Ruchika Budhiraja, Rebecca Hermkes, George Coupland and Andreas Bachmair (2012): SUMO Conjugating Enzyme with Active Site Mutation Acts as Dominant Negative Inhibitor of SUMO Conjugation in Arabidopsis. Journal of Integrative Plant Biology, Vol. 55: pp. 75-82.

47. Bojan Gujas, Carlos Alonso-Blanco and Christian S. Hardtke (2012): Natural Arabidopsis brx loss of function alleles confer root adaptation to acidic soil. Current Biology, Vol. 22: pp. 1962-1968.

46. Eavan Dorcey, Antia Rodriguez-Villalon, Paula Salinas, Luca Santuari, Sylvain Pradervand, Keith Harshman and Christian S. Hardtke (2012): Context-dependent dual role of SKI8 homologs in mRNA synthesis and turnover. PLoS Genetics, Vol. 8: e1002652.

45. David Pacheco-Villalobos and Christian S. Hardtke (2012): Natural genetic variation of root system architecture from Arabidopsis to Brachypodium: towards adaptive value. Philosophical Transactions of the Royal Society B, Vol. 367: pp. 1552-1558.


44. Luca Santuari, Emanuele Scacchi, Antia Rodriguez-Villalon, Paula Salinas, Esther M.N. Dohmann, Geraldine Brunoud, Teva Vernoux, Richard S. Smith and Christian S. Hardtke (2011): Positional information by differential endocytosis splits auxin response to drive Arabidopsis root meristem growth. Current Biology, Vol. 21: pp. 1918-1923.

43. Laura Ragni, Kaisa Nieminen, David Pacheco-Villalobos, Richard Sibout, Claus Schwechheimer and Christian S. Hardtke (2011): A direct stimulatory role of mobile gibberellin in Arabidopsis hypocotyl xylem expansion. The Plant Cell, Vol. 23: pp. 1322-1336.

42. Martial Sankar, Karen S. Osmont, Jacub Rolcik, Bojan Gujas, Danuse Tarkowska, Miroslav Strnad, Ioannis Xenarios and Christian S. Hardtke (2011): A qualitative continuous model of cellular auxin and brassinosteroid signaling and their crosstalk. Bioinformatics, Vol. 27, pp. 1404-1412.

41. Stephen Depuydt and Christian S. Hardtke (2011): Hormone Signalling Crosstalk in Plant Growth Regulation. Current Biology, Vol. 21: pp. R365-R373.

40. Christian S. Hardtke and Kaisa Nieminen (2011): Advances in identifying and exploiting natural genetic variation. Plant biotechnology and agriculture: Prospects for the 21st century, pp. 195-205.


39. Emanuele Scacchi, Paula Salinas, Bojan Gujas, Luca Santuari, Naden Krogan, Laura Ragni, Thomas Berleth and Christian S. Hardtke (2010): Spatio-temporal sequence of cross-regulatory events in root meristem growth. Proceedings of the National Academy of Sciences U.S.A., Vol. 107: pp. 22734-22739.

38. Luca Santuari and Christian S. Hardtke (2010): The case for resequencing studies of Arabidopsis thaliana accessions: mining the dark matter of natural genetic variation. Faculty of 1000 Reports, Vol 2: pp. 85.

37. Julien Beuchat, Emanuele Scacchi, Danuse Tarkowska, Laura Ragni, Miroslav Strnad and Christian S. Hardtke (2010): BRX promotes Arabidopsis shoot growth. New Phytologist, Vol. 188: pp. 23-29.

36. Julien Beuchat, Shuwei Li, Laura Ragni, Chikako Shindo, Michael H. Kohn and Christian S. Hardtke (2010): A hyperactive QTL allele of Arabidopsis BRX contributes to natural variation in root growth vigor. Proceedings of the National Academy of Sciences U.S.A., Vol. 107: pp. 8475-8480.

35. Luca Santuari, Sylvain Pradervand, Amelia-Maria Amiguet-Vercher, Jerome Thomas, Eavan Dorcey, Keith Harshman, Ioannis Xenarios, Thomas E. Juenger and Christian S. Hardtke (2010): Substantial deletion overlap among divergent Arabidopsis genomes revealed by intersection of short reads and tiling arrays. Genome Biology, Vol. 11: pp. R4.


34. Sébastien Haye and Christian S. Hardtke (2009): The Roundtable on Sustainable Biofuels: plant scientist input needed. Trends in Plant Science, Vol. 14: pp. 409-412.

33. Emanuele Scacchi, Karen S. Osmont, Julien Beuchat, Paula Salinas, Marisa Navarrete-Gómez, Marina Trigueros, Cristina Ferrándiz and Christian S. Hardtke (2009): Dynamic, auxin-responsive plasma membrane to nucleus movement of Arabidopsis BRX. Development, Vol. 136: pp. 2059-2067.

32. Stephanie Plantegenet, Johann Weber, Darlene R. Goldstein, Georg Zeller, Cindy Nussbaumer, Jerome Thomas, Detlef Weigel, Keith Harshman and Christian S. Hardtke (2009): Comprehensive analysis of Arabidopsis expression level polymorphisms with simple inheritance. Molecular Systems Biology, 5, 242.

31. Americo Rodrigues, Julia Santiago, Silvia Rubio, Angela Saez, Karen S. Osmont, Jose Gadea, Christian S. Hardtke and Pedro L. Rodriguez (2009): The short-rooted phenotype of the brevis radix mutant partly reflects root ABA hypersensitivity. Plant Physiology, Vol. 149: pp. 1917-28.


30. Chikako Shindo, Giorgina Bernasconi and Christian S. Hardtke (2008): Intra-specific competition reveals conditional fitness effects of single gene polymorphism at the Arabidopsis root growth regulator BRX. New Phytologist, Vol. 180: pp. 71-80.

29. Karen S. Osmont and Christian S. Hardtke (2008): The topless plant developmental phenotype explained! Genome Biology, Vol. 9: pp. 219-222.

28. Richard Sibout, Stephanie Plantegenet and Christian S. Hardtke (2008): Flowering as a condition for xylem expansion in Arabidopsis hypocotyl & root. Current Biology, Vol. 18: pp. 458-463.

27. Christian S. Hardtke and Keiko U. Torii (2008): Plant growth and development – the new wave. Current Opinions in Plant Biology, Vol. 11: pp. 1-3.


26. Christian S. Hardtke, Eavan Dorcey, Karen S. Osmont and Richard Sibout (2007): Phytohormone collaboration: zooming in on auxin-brassinosteroid interactions. Trends in Cell Biology, Vol. 17: pp. 485-492.

25. Christian S. Hardtke (2007): Transcriptional auxin-brassinosteroid crosstalk: who’s talking? BioEssays, Vol. 29: pp. 1115-1123.

24. Karen S. Osmont, Richard Sibout and Christian S. Hardtke (2007): Hidden Branches: Developments in Root System Architecture. Annual Review of Plant Biology, Vol. 58: pp. 93-113.

23. Chikako Shindo, Giorgina Bernasconi and Christian S. Hardtke (2007): Natural genetic variation in Arabidopsis: tools, traits and prospects for Evolutionary Ecology. Annals of Botany, Vol. 99: pp. 1043-1054.


22. Richard Sibout, Poornima Sukuma, Chamari Hettiarachchi, Magnus Holm, Gloria K. Muday and Christian S. Hardtke (2006): Opposite root growth phenotypes of hy5 vs. hy5 hyh mutants correlate with increased constitutive auxin signaling. PLoS Genetics, Vol. 2: pp. 1898-1911, e202.

21. Céline F. Mouchel, Karen S. Osmont and Christian S. Hardtke (2006): BRX mediates feedback between brassinosteroid levels and auxin signalling in root growth. Nature, Vol. 443: pp. 458-461.

20. Georgette C. Briggs, Karen S. Osmont, Chikako Shindo, Richard Sibout and Christian S. Hardtke (2006): Unequal genetic redundancies in Arabidopsis – a neglected phenomenon? Trends in Plant Sciences, Vol. 11: pp. 492-498.

19. Georgette C. Briggs, Céline F. Mouchel and Christian S. Hardtke (2006): Characterization of the plant-specific BRX gene family reveals limited genetic redundancy despite high sequence conservation. Plant Physiology, Vol. 140: pp. 1306-1316.

18. Christian S. Hardtke (2006): Root development – branching into novel spheres. Current Opinions in Plant Biology, Vol. 9: pp. 66-71.


17. Céline F. Mouchel, Georgette C. Briggs and Christian S. Hardtke (2004): Natural genetic variation in Arabidopsis identifies BREVIS RADIX, a novel regulator of cell proliferation and elongation in the root. Genes & Development, Vol. 18: pp. 700-714.

16. Corinne P. Cluis, Céline F. Mouchel and Christian S. Hardtke (2004): The Arabidopsis transcription factor HY5 integrates light and hormone signaling pathways. The Plant Journal, Vol. 38: pp. 332-347.

15. Christian S. Hardtke, Wenzislava Ckurshumova, Danielle P. Vidaurre, Sasha A. Singh, George Stamatiou, Shiv B. Tiwari, Gretchen Hagen, Tom J. Guilfoyle and Thomas Berleth (2004): Overlapping and non-redundant functions of the Arabidopsis Auxin Response Factors MONOPTEROS and NONPHOTOTROPIC HYPOCOTYL 4. Development, Vol. 131: pp. 1089-1100.


14. Christian S. Hardtke, 2003: Gibberellin Signaling: GRASs Growing Roots. Current Biology, Vol. 13: pp. R366-R367.


13. Peter Kosarev, Klaus F.X. Mayer and Christian S. Hardtke (2002): Evaluation and classification of RING finger domains encoded by the Arabidopsis genome. Genome Biology, Vol. 3: pp. 16.1-16.12.

12. Christian S. Hardtke, Haruko Okamoto, Chatanika Stoop-Myer and Xing-Wang Deng (2002): Biochemical evidence for ubiquitin ligase activity of the COP1 interacting protein CIP8. The Plant Journal, Vol. 30: pp. 385-394.

CSH’s peer-reviewed publications before he had his own lab


11. Magnus Holm, Christian S. Hardtke, Rachelle Gaudet and Xing-Wang Deng (2001): Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1. The EMBO Journal, Vol. 20: pp. 118-127.


10. Christian S. Hardtke and Xing-Wang Deng (2000): The cell biology of the COP/DET/FUS proteins. Regulating proteolysis in photomorphogenesis and beyond? Plant Physiology, Vol. 124: pp. 1548-1557.

9. Christian S. Hardtke, Kazuhito Gohda, Mark T. Osterlund, Tokitaka Oyama, Kiyotaka Okada and Xing-Wang Deng (2000): HY5 stability and activity in Arabidopsis is regulated by a phosphorylation in its COP1 binding domain. The EMBO Journal, Vol. 19: pp. 4997-5006.

8. Mark T. Osterlund, Christian S. Hardtke, Ning Wei and Xing-Wang Deng (2000): Targeted destabilization of HY5 during light-regulated development of Arabidopsis. Nature, Vol. 405: pp. 462-466.

7. Thomas Berleth, Jim Mattsson and Christian S. Hardtke (2000): Vascular continuity and auxin signals. Trends in Plant Sciences, Vol. 5: pp. 387-393.

6. Thomas Berleth, Jim Mattsson and Christian S. Hardtke (2000): Vascular continuity, cell axialization and auxin. Plant Growth Regulation, Vol. 32: pp. 173-185.


5. Christian S. Hardtke and Thomas Berleth (1998): The Arabidopsis gene MONOPTEROS encodes a transcription factor mediating embryo axis formation and vascular development. The EMBO Journal, Vol. 17: pp. 1405-1411.


4. Thomas Berleth, Christian S. Hardtke, Gerhard K.H. Przemeck and Judith Müller (1996): Mutational analysis of root initiation in the Arabidopsis embryo. Plant and Soil, Vol. 187: pp. 1-9.

3. Christian S. Hardtke and Thomas Berleth (1996): Genetic and contig map of a 2200-kb region encompassing 5.5 cM on chromosome 1 of Arabidopsis thaliana. Genome, Vol. 39: pp. 1086-1092.

2. Christian S. Hardtke, Judith Müller and Thomas Berleth (1996): Genetic similarity among Arabidopsis thaliana ecotypes estimated from DNA sequence comparison. Plant Molecular Biology, Vol. 32: pp. 915-922.

1. Gerhard K.H. Przemeck, Jim Mattsson, Christian S. Hardtke, Z. Renée Sung and Thomas Berleth (1996): Studies on the role of the Arabidopsis gene MONOPTEROS in vascular development and plant cell axialization. Planta, Vol. 200: pp. 229-237.