With use of Magnetic Resonance Images the ‘connectome’ is now accessible at millimeter scale. With our approach described in [cammoun et al. 2012], the structural connection matrix derived from diffusion MRI tractography could be constructed at 5 different scales for multiples needs.
With this method we could for instance study the architecture of a specific area; we are investigating auditory area connections of the human cortex. Another approach is to use the resting state images to analyse fuinctionnal networks. For example, Pearson correlations between the mean signals over each pair of ROIs can be use to fill a functional connectivity matrix. In this context we are conducting several projects in collaboration with the Prismatic adaptation project to analyse the changes in functional connectivity after a specific cognitive training.
Prof. Stephanie Clarke
Louis Gudmundsson, Doctoral MD student, Faculty of Biology and Medecine, Lausanne University
Manon Durand-Ruel, EPFL Life sciences, Master student, trainee
Dr Alessandra Griffa (Radiology Department, CHUV)
Dr. Patric Hagmann (Radiology Department, CHUV)
Prof. Reto Meuli (Radiology Department, CHUV)
Prof. Jean Philippe Thiran (EPFL)
Swiss National Science Foundation grants 3200030-124897 and 320030B-141177