Jack Rhodes, Huanjie Yang, Steven Moussu, Freddy Boutrot, Julia Santiago and Cyril Zipfel. Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2. Nat Communications 12, 705 (2021).

Raphaël Groux, Elia Stahl, Caroline Gouhier-Darimont, Envel Kerdaffrec, Pedro Jimenez-Sandoval, Julia Santiago, and Philippe Reymond. Arabidopsis natural variation in insect egg-induced cell death reveals a role for LECTIN RECEPTOR KINASE-I.1 Plant Physiology, Volume 185, Issue 1, January 2021, Pages 240–255.

del Hierro, Irene; Mélida, Hugo; Broyart, Caroline; Santiago, Julia; Molina, Antonio. Computational prediction method to decipher receptor-glycoligand interactions in plant immunity. The Plant Journal (2021) 105, 1710–1726.


Moussu S*, Broyart C*, Santos-Fernandez G*, Augustin S, Wehrle S, Grossniklaus U, Santiago J: Structural basis for recognition of RALF peptides by LRX proteins during pollen tube growth. Proceedings of the National Academy of Science 2020.

Jimenez-Sandoval P, Santiago J: In vitro analytical approaches to study plant ligand-receptor interactions. Plant Physiology 2020.


Moussu S, Santiago J: Structural biology of cell surface receptor–ligand interactions. Current Opinion in Plant Biology 2019, 52:38–45


Moussu S, Augustin S, Roman A-O, Broyart C, Santiago J: Crystal structures of two tandem malectin-like receptor kinases involved in plant reproduction. Acta Cryst D 2018, 74:671–680.

Ulrich Hohmann, Julia Santiago, Joël Nicolet, Vilde Olsson, Fabio M. Spiga, Ludwig A. Hothorn, Melinka A. Butenko, and Michael Hothorn . Mechanistic basis for the activation of plant membrane receptor kinases by SERK-family coreceptors. PNAS 2018, 115 (13) 3488-3493.


Ora Hazak*, Benjamin Brandt*, Pietro Cattaneo, Julia Santiago, Antia Rodriguez-Villalon, Michael Hothorn$ and Christian S. Hardtke$. Perception of root-active CLE peptides requires CORYNE function in phloem vasculature. EMBO Reports 2017, 18:1367-1381.


Santiago J$, Brandt B, Wildhagen M, Hohmann U, Hothorn LA, Butenko MA, Hothorn M$. Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission.
eLife 2016, doi: 10.7554/eLife.15075


Faus I, Zabalza A, Santiago J, Nebauer SG, Royuela M, Serrano R, Gadea J. Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis. BMC Plant Biol 2015, 15(1):14.


Bojar D, Martinez J, Santiago J, Rybin V, Bayliss R, Hothorn M. Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation. Plant Journal 2014, 78:31-43.



Santiago J, Henzler C, Hothorn M. Molecular Mechanism for Plant Steroid Receptor Activation by Somatic Embryogenesis Co-Receptor Kinases. Science 2013, 341:889-92.

doi: 10.1126/science.1242468


Santiago, J., Dupeux, F., Betz, K., Antoni, R., Gonzalez-Guzman, M., Rodriguez, L., Marquez, J.A., Rodriguez, P. L. Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs. Plant Science 2012, 182, 3-11.

doi: 10.1016/j.plantsci.2010.11.014


Dupeux, F*., Santiago, J*., Betz, K*., Twycross, J., Park, S. Y., Rodriguez, L., Gonzalez-Guzman,  M., Jensen, M. R., Krasnogor, N., Blackledge, M., Holdsworth, M., Cutler, S. R., Rodriguez, P. L., Marquez, J. A. A thermodynamic switch modulates abscisic acid receptor sensitivity. EMBO Journal 2011, 30, 4171-4184.


Park, S. Y., Fung, P., Nishimura, N., Jensen, D. R., Fujii, H., Zhao, Y., Lumba, S., Santiago, J., Rodrigues, A., Chow, T. F., Alfred, S. E., Bonetta, D., Finkelstein, R., Provart, N. J., Desveaux, D., Rodriguez, P. L., McCourt, P., Zhu, J. K., Schroeder, J. I., Volkman, B. F., Cutler, S. R. Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science 2009, 324, 1068-1071.

doi: 10.1126/science.1173041

[Santiago, J*., Rodrigues, A*., Saez, A., Rubio, S., Antoni, R., Dupeux, F., Park, S. Y., Marquez, J. A., Cutler, S. R., Rodriguez, P. L. Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs.  Plant Journal 2009, 60, 575-588.]

Santiago, J*., Dupeux, F*., Round, A., Antoni, R., Park, S. Y., Jamin, M., Cutler, S. R., Rodriguez, P. L., Marquez, J. A. The abscisic acid receptor PYR1 in complex with abscisic acid. Nature 2009, 462, 665-668.

Rodrigues, A*., Santiago, J*., Rubio, S., Saez, A., Osmont, K. S., Gadea, J., Hardtke, C. S.Rodriguez, P. L. The short-rooted phenotype of the brevis radix mutant partly reflects root abscisic acid hypersensitivity. Plant Physiology 2009, 149, 1917-1928.


[Rubio, S., Rodrigues, A., Saez, A., Dizon, M. B., Galle, A., Kim, T. H., Santiago, J., Flexas, J., Schroeder, J. I., Rodriguez, P. L. Triple loss of function of protein phosphatases type 2C leads to partial constitutive response to endogenous abscisic acid. Plant Physiology 2009, 150, 1345-1355.]

Gimeno, J., Gadea, J., Forment, J., Perez-Valle, J., Santiago, J., Martinez-Godoy, M. A., Yenush, L., Belles, J. M., Brumos, J., Colmenero-Flores, J. M., Talon, M., Serrano, R. Shared and novel molecular responses of mandarin to drought. Plant Molecular Biology 2009, 70, 403-420.


[Saez, A., Rodrigues, A., Santiago, J., Rubio, S., Rodriguez, P. L. HAB1-SWI3B interaction reveals a link between abscisic acid signaling and putative SWI/SNF chromatin-remodeling complexes in Arabidopsis. Plant Cell 2008, 20, 2972-2988.]

Martinez-Godoy, M. A., Mauri, N., Juarez, J., Marques, M. C., Santiago, J., Forment, J., Gadea, J. A genome-wide 20 K citrus microarray for gene expression analysis. BMC Genomics 2008,  9, 318-321.

* Authors contributed equally to this work

$ corresponding author