Pathophysiology & molecular mechanisms

To date, there is no effective treatment available for stunting. This is mainly because the pathophysiological mechanisms underlying nutrition-related dysbiosis remain elusive.

We work on untangling the role of the microbiome, (asymptomatic) enteric infections, inflammation and nutrition on the gut ecosystem, metabolism and systemic changes. To this purpose, we use different animal models as well as cell culture/ in vitro based approaches to infer causal relationship between these different entities and try to unravel the underlying molecular mechanisms. Better understanding the pathophysiological mechanisms will allow us to subsequently target these Achilles heels and hopefully contribute to a more efficient treatment of these syndromes in the future.