PhD Student
A PhD. position is available at the Department of Biomedical Sciences (DBS) in the University of Lausanne (UNIL), within the Laboratory of Regenerative Hematopoiesis led by Prof. Olaia Naveiras, MD/PhD The project, entitled “Revitalizing the aged immune system by partial reprogramming of the immune, hematopoietic and stromal compartments”, aims to demonstrate the concept that partial reprogramming can restore the aged immune response and generate key insights into the aging hematopoietic system. The project goal is to elucidate the aged immune response at the single-cell level, develop
novel reprogrammable strains, optimize partial reprogramming protocols, and enhance the resilience of the aged immune system. The candidate would work in close collaboration with post-doctoral fellow Dr. Gabriela Desdin-Mico. As a trainee, you will be able to delve into various topics spanning immune aging, hematopoietic stem cells, and bone marrow stromal niche biology. Throughout this project, the PhD student will gain valuable expertise in:
- Infection assays and in vivo reprogramming mouse models.
- Immunofluorescence and immunophenotyping by flow cytometry.
- Bulk and single-cell transcriptomic analyses
The ideal candidate should meet the following criteria: - Comply with the requirements for the UNIL PhD Program in Cancer and Immunology requirements
- Work experience in wet lab (immunoblotting, flow cytometry, PCR)
- Experience with in vivo mouse research
- Prior experience with bioinformatics (scRNAseq analysis a valuable plus)
- Excellent English communication skills is a plus
- Independent, flexible, reliable, enthusiastic, and collaborative-minded team player
Preference will be given to outstanding candidates who can start in June 2024.
Who are we?
Our laboratory focuses on gaining deeper insights into the bone marrow microenvironment within bone marrow failure syndromes. Cell biology, bio-engineering, and clinical hematology approaches represent the laboratory fundamental pillars that provide high-standard research with clinically translational outcomes. All this is possible thanks to the UNIL biomedical campus at CHUV where the laboratory is located. UNIL is a leading international teaching and research institution, with over 5,000 employees and 17,000 students split between its Dorigny campus, CHUV, and Epalinges. The DBS is the main pole for research activities in metabolic, cardiovascular, and renal diseases, regenerative medicine, and aging, and is a privileged site of interaction with the Clinical Services of the Lausanne University Hospital (CHUV).
How to Apply?
Interested applicants who meet all the requirements should send their CV and a motivation letter in an email entitled “Hevolution PhD application” to Prof. Naveiras (olaia.naveiras@unil.ch) and Dr. Desdin-Mico (gabriela.desdin@unil.ch) by April 3rd at the latest. Selected candidates will be invited to participate in person for a laboratory visit on April 11th, which includes an oral presentation and personal interviews (this can also be done online). Administrative and eligibility questions should be directed to the respective PhD program administrators (cancerimmunology@unil.ch).