{"id":322,"date":"2012-08-27T14:06:46","date_gmt":"2012-08-27T12:06:46","guid":{"rendered":"http:\/\/wp.unil.ch\/sgg\/?p=322"},"modified":"2012-08-27T14:06:46","modified_gmt":"2012-08-27T12:06:46","slug":"two-novel-snps-associated-with-hcv-induced-fibrosis-progression","status":"publish","type":"post","link":"https:\/\/wp.unil.ch\/sgg\/2012\/08\/two-novel-snps-associated-with-hcv-induced-fibrosis-progression\/","title":{"rendered":"Two novel SNPs associated with HCV-induced fibrosis progression"},"content":{"rendered":"<div>\n<p id=\"sp0120\">Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We studied well-characterized HCV-infected patients of European descent who underwent liver biopsies before treatment.<\/p>\n<p><!--more-->We defined various liver fibrosis phenotypes on the basis of METAVIR scores, with and without taking the duration of HCV infection into account. Our GWA analyses were conducted on a primary cohort of ~1200 patients using 780K single nucleotide polymorphisms (SNPs). We genotyped 96 SNPs with <em>P<\/em> values &lt;5 \u00d7 10<sup>?5<\/sup> from an independent replication cohort of ~1200 patients. In the combined cohort of ~2400 HCV-infected patients, the SNPs rs16851720 (in the total sample) and rs4374383 (in patients who received blood transfusions) were associated with fibrosis progression (<em>P<\/em><sub>combined<\/sub> = 8.9 \u00d7 10<sup>?9<\/sup> and 1.1 \u00d7 10<sup>?9<\/sup>, respectively). The SNP rs16851720 is located within <em>RNF7<\/em>, which encodes an antioxidant that protects against apoptosis. SNP rs4374383 is linked to the functionally related gene <em>MERTK<\/em><em><\/em>, which encode factors involved in phagocytosis of apoptotic cells by macrophages. Our GWA study identified several susceptibility loci for HCV-induced liver fibrosis; these were linked to genes that regulate apoptosis. Apoptotic control might therefore be involved in liver fibrosis.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We studied well-characterized HCV-infected patients of European descent &hellip; <\/p>\n","protected":false},"author":970,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"categories":[115],"tags":[],"class_list":{"0":"post-322","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-non-classe"},"_links":{"self":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/posts\/322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/users\/970"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/comments?post=322"}],"version-history":[{"count":0,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/posts\/322\/revisions"}],"wp:attachment":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/media?parent=322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/categories?post=322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/tags?post=322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}