{"id":1423,"date":"2020-09-01T14:38:22","date_gmt":"2020-09-01T12:38:22","guid":{"rendered":"http:\/\/wp.unil.ch\/sgg\/?page_id=1423"},"modified":"2021-08-09T10:44:36","modified_gmt":"2021-08-09T08:44:36","slug":"pca-mr","status":"publish","type":"page","link":"https:\/\/wp.unil.ch\/sgg\/pca-mr\/","title":{"rendered":"PCA-MR"},"content":{"rendered":"<p>This page provides an overview of our <strong>PCA cross-sex MR<\/strong> approach, combining a method to calculate effect estimates from a linear combination of traits from summary statistics and a Mendelian randomisation framework to minimise the bias from a single sample setting.<\/p>\n<p>The manuscript can be found on bioRxiv.<\/p>\n<p>The results can be navigated using the shiny app. The code can be downloaded\/cloned from GitHub: <a href=\"https:\/\/github.com\/JonSulc\/PCA_Cross-sex_MR\">https:\/\/github.com\/JonSulc\/PCA_Cross-sex_MR<\/a> and the required input data files along with the\u00a0generated genome-wide summary statistics can be downloaded from <a href=\"https:\/\/zenodo.org\/record\/5171807\">here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This page provides an overview of our PCA cross-sex MR approach, combining a method to calculate effect estimates from a linear combination of traits from summary statistics and a Mendelian &hellip; <\/p>\n","protected":false},"author":970,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-1423","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/pages\/1423","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/users\/970"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/comments?post=1423"}],"version-history":[{"count":0,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/pages\/1423\/revisions"}],"wp:attachment":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/media?parent=1423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}