{"id":1314,"date":"2019-06-24T11:39:16","date_gmt":"2019-06-24T09:39:16","guid":{"rendered":"http:\/\/wp.unil.ch\/sgg\/?page_id=1314"},"modified":"2019-06-24T11:39:16","modified_gmt":"2019-06-24T09:39:16","slug":"fbm-phd-fellowship","status":"publish","type":"page","link":"https:\/\/wp.unil.ch\/sgg\/fbm-phd-fellowship\/","title":{"rendered":"FBM PhD fellowship"},"content":{"rendered":"<p><strong>Inference of causal biomarker network to boost drug repositioning and minimise side effects<\/strong><\/p>\n<p>Epidemiological studies are predominantly observational, from which drawing causal inference remains a major challenge. Mendelian randomisation (MR) studies harness robust genetic associations to infer potential causal effect of an exposure on outcomes. In this project we will derive and integrate gene-disease and gene regulatory networks with data linking drugs and genes (Connectivity Map, DSigDB, etc.) to improve drug-repositioning efforts. All developed methods will be applied to simulated- and real data from large biobanks (UK, Estonia) with gene\/protein expression levels as exposures and cardio-metabolic diseases as outcomes. The most promising therapeutic solutions will then be validated through a longitudinal study (FinnGen) with extensive information on medication use and health outcomes. The generated knowledge will accelerate drug discovery\/repositioning.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Inference of causal biomarker network to boost drug repositioning and minimise side effects Epidemiological studies are predominantly observational, from which drawing causal inference remains a major challenge. Mendelian randomisation (MR) &hellip; <\/p>\n","protected":false},"author":970,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"footnotes":""},"class_list":["post-1314","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/pages\/1314","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/users\/970"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/comments?post=1314"}],"version-history":[{"count":0,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/pages\/1314\/revisions"}],"wp:attachment":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/media?parent=1314"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}