{"id":1095,"date":"2017-04-26T00:04:04","date_gmt":"2017-04-25T22:04:04","guid":{"rendered":"http:\/\/wp.unil.ch\/sgg\/?page_id=1095"},"modified":"2020-03-03T15:49:46","modified_gmt":"2020-03-03T14:49:46","slug":"bayesian-lifespan-gwas","status":"publish","type":"page","link":"https:\/\/wp.unil.ch\/sgg\/bayesian-lifespan-gwas\/","title":{"rendered":"Bayesian lifespan GWAS"},"content":{"rendered":"<p><strong>Bayesian association scan reveals loci associated with human lifespan and linked biomarkers<\/strong><\/p>\n<p>The enormous variations in human lifespan are in part due to a myriad of sequence variants, only a few of which have been revealed to date. Since many life-shortening events are related to diseases, we developed a Mendelian randomization-based method combining 58 disease-related GWA studies to derive longevity priors for all HapMap SNPs. A Bayesian association scan, informed by these priors, for parental age of death in the UK Biobank study (n=116,279) revealed 16 independent SNPs with significant Bayes factor at a 5% false discovery rate (FDR). Eleven of them replicate (5% FDR) in five independent longevity studies combined; all but three are depleted of the life-shortening alleles in older Biobank participants. Further analysis revealed that brain expression levels of nearby genes (RBM6, SULT1A1, CHRNA5) might be causally implicated in longevity. Gene-expression and caloric restriction experiments in model organisms confirm the conserved role for RBM6 and SULT1A1 in modulating lifespan.<\/p>\n<p><em>The genome-wide summary statistics, including priors, test-statistics, Bayes factors and permutation-based P-values are available for download from <a href=\"https:\/\/www.dropbox.com\/s\/1svglqp9ly383r2\/gwas.of.important.info.csv.gz?dl=0\">here<\/a>.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bayesian association scan reveals loci associated with human lifespan and linked biomarkers The enormous variations in human lifespan are in part due to a myriad of sequence variants, only a &hellip; <\/p>\n","protected":false},"author":970,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-1095","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/pages\/1095","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/users\/970"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/comments?post=1095"}],"version-history":[{"count":0,"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/pages\/1095\/revisions"}],"wp:attachment":[{"href":"https:\/\/wp.unil.ch\/sgg\/wp-json\/wp\/v2\/media?parent=1095"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}