{"id":199,"date":"2016-03-07T10:40:27","date_gmt":"2016-03-07T09:40:27","guid":{"rendered":"http:\/\/wp.unil.ch\/lhop\/?page_id=199"},"modified":"2023-10-12T21:45:57","modified_gmt":"2023-10-12T19:45:57","slug":"news","status":"publish","type":"page","link":"https:\/\/wp.unil.ch\/lhop\/news\/","title":{"rendered":"News !"},"content":{"rendered":"
\n

10 October 2023<\/strong><\/p>\n

\"\"<\/p>\n

Our LHOP Biobank received the SBP VITA Label\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \"\" <\/strong><\/p>\n

Building up a proper Governance through accountable mechanisms is key to foster trustworthiness and the prerequisite for the appropriate use of biological resources. Our LHOP Biobank has recently been awarded by Swiss Biobanking Platform (SBP) with the VITA Label, which demonstrates compliance with the applicable legal and ethical framework. This labelling approach is part of our long-term strategy to strengthen biobanking practices and provide high-quality samples to the research community.<\/p>\n

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26th April 2023<\/strong><\/p>\n

Congratulations to Dr Nastassia Gobet who has obtained her PhD doctoral degree from the University of Lausanne.<\/p>\n

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15th March 2023<\/strong><\/p>\n

The LHOP has just welcomed a new PhD student! Estelle Guillot will be working on a project of Dr Annick M\u00fchlethaler (Neuroblastoma Subgroup) funded by the Childhood Cancer Research Foundation Switzerland.<\/p>\n

\n

11th December 2022<\/b><\/p>\n

\"\"The LHOP just delivered an oral presentations at the 60th Meeting of the American Society of Hematology in New Orleans, USA! Our post-doc Julien Delobel presented on “Proteomic and Lipidomic Investigation of an Ex-Vivo Human Model of Sickle Cell Disease Erythropoiesis and Patient Erythrocytes Reveals the Abnormal Localization and Dysfunction of the Proteasome, Disrupted Antioxidant Defenses and Altered Lipid Profiles”. Click here for the abstract<\/a> published in the ASH proceedings in Blood.<\/p>\n

This important study resulted from a collaboration with the EPFL in Lausanne.\u00a0In addition, congrats to Julien Delobel who received an ASH Abstract Achievement Award<\/strong> for his work! This is a fantastic achievement.<\/p>\n

\n

4th November 2022<\/b><\/p>\n

\"\"<\/p>\n

Exciting paper from the Michel Prudent lab at the CRS-TIR laboratory in Epalinges, Switzerland just having been accepted for publication in Blood Transfusion! The team of the LHOP (Dr Delobel and Dr Renella) were collaborators in this study generating a new transfusion model. \u00a0Please\u00a0click here<\/a> for more information and manuscript download.<\/p>\n

\n

1st of October 2022<\/b><\/p>\n

The LHOP has just welcomed two new members!<\/p>\n

PhD-candidate Nastassia Gobet will be working on the \u00a0optimal harnessing of complex research datasets in pediatric hematology-oncology.<\/p>\n

Dr Luisa Cironi, a longstanding researcher in the pathogenesis of pediatric cancer, will be a wonderful addition to our expertise in the field.<\/p>\n

We are all very excited about this new members of the LHOP and welcome them warmly!<\/p>\n

\n

13th of July 2022<\/b><\/p>\n

\"\"The LHOP has just received a 3-year grant from the FORCE – Fondation pour la Recherche sur le Cancer de l’Enfant for the optimal harnessing of complex research datasets in pediatric hematology-oncology.<\/p>\n

This generous support will allow us to welcome a new collaborator! We welcome Nastassia Gobet, MSc, coming from the UNIL for this new exciting development.<\/p>\n

\n

12th of January 2022<\/span><\/p>\n

\"\"Congratulations to Dr Vittoria Sepporta PhD, a laboratory post-doctoral researcher, for the publication of seminal work on the role of the transcription factor TWIST1 in neuroblastoma (NB)! This very important study performed in the laboratory and led by Dr Annick M\u00fchlethaler PhD has just been published in Communications Biology. Vittoria and the team show that an\u00a0association of TWIST1 expression with poor survival and metastasis in primary NB,
\nand identify a TWIST1-mediated transcriptional program associated with dismal outcome in NB. The manuscript is accessible openly by clicking\u00a0here<\/a>.<\/p>\n

\n

6th of January 2022<\/span><\/p>\n

\"\"<\/p>\n

Exciting news for Dr Raffaele Renella, our lab head, who has accepted to become Associate Editor of the Elsevier journal : “Blood Cells: Molecules & Disease.” \u00a0Established in 1975 under the editorship of Marcel Bessis, it was lead over the years by hematology pioneers such as Ernest Beutler, Marshall Lichtman and Mohandas Narla. Raffaele will be working alongside\u00a0Lionel Blanc PhD (Feinstein Institutes for Medical Research, New York, USA), the journal’s new Editor in Chief. Check out the journal by clicking here<\/a>.<\/p>\n

\n

9th of November 2021<\/span><\/p>\n

\"\"Very exciting paper from the laboratory just having been accepted for publication in American Journal of Hematology! After 10 years of investigation of a unique phenotype in an infant with neutropenia, Dr Renella and collaborators from Boston Children’s Hospital & Harvard Medical School, delineate a new disorder of myelopoiesis in children linked to a germline mutation in SEPT6. \u00a0Please\u00a0click here<\/a> for more information and manuscript download.<\/p>\n

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10th of September 2021<\/span><\/p>\n

\"\"<\/p>\n

Congratulations to Vittoria Sepporta and Julien Delobel for winning an award at the Department “Woman-Mother-Child” research Day 2021! The lab wins 2 of the four available prizes! Amazing! Congratulations to Vittoria and Julien! Also a time to celebrate as a group…. (as if excuses were needed!)<\/p>\n

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15th of April 2021<\/span><\/p>\n

The lab is very excited to welcome a new PhD candidate student to our community. Mrs Maya El-Natour will be working on the project of Dr Annick M\u00fchlethaler (Neuroblastoma Subgroup) funded by the Swiss National Science Foundation. This\u00a04-year SNSF Research grant for a project entitled “Deciphering the functional role of ALK and TWIST1 in neuroblastoma development and progression” has recently been awarded to Annick and the lab.\u00a0Welcome to her and all the best for breaking new boundaries in neuroblastoma research!\u00a0<\/span><\/p>\n

\n

4th December 2020 \u00a0<\/b><\/p>\n

\"\"<\/p>\n

Big day for the lab! Thanks to the generous support from the Loterie Romande (see news below 13th Sep. 2019), \u00a0 and the Fondation Plan\u00e8te Enfants Malades, we have completed the installation of brand new Laser Optical Rotational Red Cell Analyser (Lorrca) allowing us to perform cutting edge ektacytometry in varying osmolarity and oxygen tension conditions! We are incredibly excited and grateful \u00a0to be the guardians of one of the few machines available world-wide, and advance our field of red cell biology with our national and international collaborators. If you are interested in collaborations with us, don’t hesitate to contact us.<\/p>\n

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\u00a0\u00a0<\/b><\/p>\n

25th of August 2020 \u00a0<\/b><\/p>\n

\"\"<\/p>\n

Congratulations to Dr Lucie Vivancos,\u00a0who has been awarded her PhD doctoral degree from the University of Lausanne for her discoveries on the role of ALK in the formation of neuroblastoma! This has given us a COVID-19-reglementary ap\u00e9ro on the terrace of the main hospital building and celebrate with the team & friends\/colleagues.<\/p>\n

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10th of August 2020\u00a0<\/b><\/p>\n

\"\"<\/p>\n

Congratulations to our Lab Head Dr Raffaele Renella who has been awarded a research grant from the Mach-Gaensslen Foundation for Medical Research for his investigation of sickle cell disease lipidomics.<\/p>\n

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27th September 2019<\/b><\/p>\n

\"\"Wonderful news! The LHOP has been awarded a 4-year SNSF Research grant for a project entitled “Deciphering the functional role of ALK and TWIST1 in neuroblastoma development and progression”. Congratulation to Annick M\u00fchlethaler who will be the PI for this work! This phenomenal support will further strengthen and foster the LHOP’s expertise and decade-long experience in the field of neuroblastoma.<\/p>\n

\n

13th September 2019<\/b><\/p>\n

\"\"The LHOP has been awarded a very generous research equipment grant from the Loterie Romande for the acquisition of a erythocyte ekatcytometer with the capacity to study red cells in health and disease under variable osmotic and oxygen-tension conditions! This will be one of the very few machines available in Europe at this time. We are immensely grateful for this support!<\/p>\n

\n

28th August 2019<\/b><\/p>\n

\"\"Congratulations to Fr\u00e9derica Schyrr for her paper just having been accepted for publication in American Journal of Hematology! This manuscript delineates the optimal preoperative care of children with sickle cell disease. Fr\u00e9derica and the team performed a very extensive systematic review and issued key recommendations that will most certainly impact care. Please\u00a0click here<\/a> for more information and manuscript download.<\/p>\n

\n

14th of June 2019<\/b><\/p>\n

\"\"Congratulations to our Lab Head Dr Raffaele Renella who has been awarded a research grant from the Novartis’ Foundation of Medical-Biological research for this project on erythroid multiomics.<\/p>\n

\n

22nd May 2019<\/b><\/p>\n

\"\"Congratulations to MD-PhD Student Fr\u00e9d\u00e9rica Schyrr (member of the Naveiras Laboratory<\/a> at the EPFL) whose abstract on a PRISMA-based systematic review on the perioperative care of children and adults with sickle cell disease has been selected for poster presentation at the 24th European Hematology Association<\/a> Congress in Amsterdam (Netherlands). This very important collaborative effort under the supervision of our Lab Head Dr Raffaele Renella has helped to highlight recommendations, devise a risk-assessment algorithm and identify research priorities in this area.<\/p>\n

\n

25th March 2019<\/b><\/p>\n

\"\"Congratulations to Lucie Vivancos Stalin for her paper just having been accepted for publication in Frontiers in Oncology! This great contribution is reporting on\u00a0the expression of the neuroblastoma-associated ALK-F1174L activating mutation during embryogenesis, and the associated impairment in the differentiation of neural crest progenitors in sympathetic ganglia. \u00a0Lucie and colleagues\u00a0report for the first time that the expression of the human ALK-F1174L mutation in NCCs during embryonic development profoundly disturbs early sympathetic progenitor differentiation, in addition to increasing their proliferation, both mechanisms being potential crucial events in NB oncogenesis. \u00a0Please\u00a0click here<\/a> for more information and manuscript download.<\/p>\n

\n

12th March 2019<\/b><\/p>\n

\"\"Congratulations to Julien Delobel, post-doc in the lab, who won the “Best Contribution” award at the 22nd European Red Blood Cell Society (ERCS) Meeting in Ascona, Switzerland! The lab was well represented at this event with 2 oral presentations, on developing newborn screening for sickle cell disease with a paper-test (Delobel), and on surfaceomics of erythropoiesis in health and disease (Renella).<\/p>\n

\n

\"\"3rd December 2018<\/b><\/p>\n

AN INCREDIBLE END OF THE YEAR!<\/p>\n

The LHOP just delivered two oral presentations at the 60th Meeting of the American Society of Hematology in San Diego, California! Our post-doc Julien Delobel presented on “Harnessing the Power of Global Health Studies for Sickle Cell Disease: Validation of a Rapid, Open-Source, Paper-Based Screening Assay in a Cohort of 1103 Tanzanian Children”<\/a>, which resulted from a collaboration with the Swiss Tropical and Public Health Institute in Basel.\u00a0In addition, congrats to Julien Delobel who received an ASH Abstract Achievement Award<\/strong> for his work! This is a fantastic achievement.<\/p>\n

Our lab head\u00a0Raffaele Renella presented on “Congenital X-linked Myelodysplasia with Tetraploidy is Associated with De Novo Germline C-terminal Mutation of SEPT6, a Septin Filament Protein”<\/a>, which resulted from a collaboration with Boston Children’s Hospital, Harvard Medical School.\u00a0In addition, Raffaele Renella was invited to talk on “Seizing Opportunities in the Molecular and Cellular Dissection of Unique Phenotypes in Pediatric Myelodysplastic Syndromes” at the Scientific Workshop on Inherited Hematopoietic Malignancies.<\/p>\n

\n

7th\u00a0September\u00a02018<\/b>\"\"<\/p>\n

Sometimes it is good to celebrate a non-scientific group achievement! Our lab was able to complete the Escape Game (The Key Einstein) in Lausanne during our start of the academic year outing in 58 minutes! Clearly a world record, which was celebrated with dinner & drinks!<\/p>\n

\n

\"\"1st May 2018<\/b><\/p>\n

Congratulations to Dr Maria-Vittoria Sepporta and Lucie Vivancos, PhD candidate in the lab, who both have been selected to present their research at the\u00a0Advances in Neuroblastoma Research Conference, scheduled for May 9, 2018 \u2013 May 12, 2018, at the San Francisco Hyatt Regency Hotel.<\/p>\n

\n

9th of\u00a0<\/strong>January 2017<\/b><\/p>\n

We are delighted to welcome Dr Julien Delobel<\/a> PhD\u00a0to our laboratory. Julien\u00a0is coming to us from Berlin and will be a SNSF Post-doctoral\u00a0researcher\u00a0in the lab working with Dr Raffaele Renella MD PhD\u00a0on the cellular surfaceome of healthy and Sickle Cell Disease erythropoiesis.<\/p>\n

\n

10th of October 2016\u00a0<\/strong><\/p>\n

A new manuscript by the lab has just been published in BMC Cancer investigating the role of Aldehyde Dehydrogenase (ALDH)\u00a0in the aggressive phenotype of neuroblastoma! Interestingly,\u00a0the\u00a0enzymatic activity of ALDH plays a role in the\u00a0aggressive properties and the 4-hydroxycyclophosphamide resistance of NB, and our team shows\u00a0ALDH1A3 isoenzyme activity increases the aggressive capacities of a subset of NB cells. Congratulations to all of the co-authors for this great achievement and contribution.<\/p>\n

Flahaut M, Jauquier N, Chevalier N, Nardou K, Balmas Bourloud K, Joseph JM,\u00a0Barras D, Widmann C, Gross N, Renella R, M\u00fchlethaler-Mottet A. Aldehyde\u00a0dehydrogenase activity plays a key role in the aggressive phenotype of\u00a0neuroblastoma. BMC Cancer.<\/a><\/p>\n

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9th of\u00a0September 2016\u00a0<\/strong><\/p>\n

We are very excited to have a new job opening for a postdoctoral research fellow !!!! See here for details<\/a>.<\/p>\n

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6th of\u00a0September\u00a02016\u00a0<\/strong><\/p>\n

\"jci\"A paper by Drs Brendel, Guda, Renella and others under the leadership of Prof David A Williams (Boston Children’s Hospital,\u00a0Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA) reporting of a pre-clinical gene therapy study for sickle cell disease has been published in the Journal of Clinical Investigation today! In this paper, work initiated by Drs Renella and Milsom in the Williams Laboratory in 2011 has paved the way for a novel gene therapy approach for sickle cell disease, aiming at inducing the expression of fatal haemoglobin (HbF) by knocking down BCL11A, a protein involved in the haemoglobin switch. For more details and explanations please see the Harvard Medical School Gazette article<\/a>\u00a0and the\u00a0STAT website article<\/a>\u00a0covering this publication.<\/p>\n

Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. J Clin Invest. 2016<\/a><\/p>\n

\n

14th of July 2016\u00a0<\/strong><\/p>\n

\"maxresdefault\"A paper by Dr Philip Altrock (Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA) and colleagues, with the contribution of Dr Raffaele Renella, has been published early online in the American Journal of Hematology this week. It explores an integrative theoretical and experimental approach, which has identified the target frequency of HSC alterations required for effective treatment of sickling syndromes in humans. This\u00a0work replaces episodic observations of such target frequencies with a mathematical modeling framework that covers a large and continuous spectrum of chimerism conditions.\u00a0[Altrock PM, Brendel C, Renella R, Orkin SH, Williams DA, Michor F. Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease. Am J Hematol. 2016<\/a>]<\/p>\n

\n

18th of May\u00a02016\u00a0<\/strong><\/p>\n

\"coverA paper by Dr Raffaele Renella has been published early online in Proteomics – Clinical Applications this week, reviewing the challenges and opportunities of studying Sickle Cell Disease with proteomic approaches [Renella R. Clinically-oriented proteomic investigation of sickle cell disease: Opportunities and challenges. Proteomics Clin Appl. 2016<\/a>.]<\/p>\n

\n

30th March 2016\u00a0<\/strong><\/p>\n

\"ANR-2016-Draft-1\"Dr Annick M\u00fchlethaler-Mottet has been invited to give an oral as well as two poster presentations at the Advances in\u00a0Neuroblastoma Research Meeting<\/a> (ANR 2016) in Cairns (Australia) in June. Congratulations for this achievement!<\/p>\n

\n

1st February 2016<\/strong><\/p>\n

We are delighted to welcome Lucie Vivancos MSc<\/a> to our laboratory. Lucie is coming to us from the University of Marseille and will be a PhD candidate in the lab working with Dr Annick M\u00fchlethaler on the role of ALK mutations in the pathogenesis of neuroblastoma.<\/p>\n","protected":false},"excerpt":{"rendered":"

10 October 2023 Our LHOP Biobank received the SBP VITA Label\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/p>\n","protected":false},"author":1001217,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-199","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/pages\/199","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/users\/1001217"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/comments?post=199"}],"version-history":[{"count":0,"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/pages\/199\/revisions"}],"wp:attachment":[{"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/media?parent=199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}