{"id":17,"date":"2015-06-10T23:11:38","date_gmt":"2015-06-10T21:11:38","guid":{"rendered":"http:\/\/wp.unil.ch\/lhop\/?page_id=17"},"modified":"2025-08-15T09:42:21","modified_gmt":"2025-08-15T07:42:21","slug":"publications","status":"publish","type":"page","link":"https:\/\/wp.unil.ch\/lhop\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Most recent publications (2010 – today)\u00a0<\/strong><\/em><\/p>\n

\n

Neuroblastoma Subgroup<\/strong> (PI PD Dr Annick M\u00fchlethaler PhD)<\/p>\n

    \n
  1. Sundaramoorthy S, Colombo DF, Sanalkumar R, Broye L, Balmas Bourloud K, Boulay G, Cironi L, Stamenkovic I, Renella R, Kuttler F, Turcatti G, Rivera MN,\u00a0M\u00fchlethaler-Mottet A, Bardet AF, Riggi N.Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma. JCI Insight. 2024 Jul 22;9(14):e169647. Pubmed<\/a><\/li>\n
  2. M\u00fchlethaler-Mottet A, Uccella S, Marchiori D, La Rosa S, Daraspe J, Balmas Bourloud K, Beck Popovic M, Eugster PJ, Grouzmann E, Abid K. Low number of neurosecretory vesicles in neuroblastoma impairs massive catecholamine release and prevents hypertension.\u00a0Front Endocrinol. 2022. Pubmed<\/a><\/li>\n
  3. Maria-Vittoria Sepporta, Viviane Praz, Katia Balmas Bourloud, Jean-Marc Joseph, Nicolas Jauquier, Nicolo Riggi, Katya Nardou-Auderset, Audrey Petit, Jean-Yves Scoazec, Herv\u00e9 Sartelet, Raffaele Renella, Annick M\u00fchlethaler-Mottet. TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growth. Commun Biol<\/em> 2022. Pubmed<\/a><\/li>\n
  4. Bellini A., P\u00f6tschger U., Bernard V., Lapouble E., Baulande S., Ambros P.F., Auger N., Beiske K, Bernkopf M., Betts D.R., Bhalshankar J., Bown N.,\u00a0 de Preter K, Cl\u00e9ment N.,\u00a0 Combaret V., Font de Mora J., George S.L., Jim\u00e9nez I., Jeison M, Marques B, Martinsson T., Mazzocco K, Morini M., M\u00fchlethaler-Mottet A., Noguera R., Pierron G., Rossing C.M., Taschner-Mandl S., Van Roy N., Vicha A., Chesler L., Balwierz W., Castel V., Elliott M., Kogner P.,\u00a0 Laureys G., Luksch R., Malis J., Popovic-Beck M.,\u00a0 Ash S., Delattre O., Valteau-Couanet D., Tweddle D.A., Ladenstein R., Schleiermacher G. Frequency and prognostic impact of ALK amplifications and mutations in the European Neuroblastoma Study Group (SIOPEN) high-risk neuroblastoma trial\u00a0 (HR-NBL1). J Clin Oncol. 2021. Pubmed<\/a><\/li>\n
  5. Karim Abid, Maja Beck Popovic, Katia Balmas Bourloud, Jacqueline Schoumans, Joana Grand-Guillaume, Eric Grouzmann and Annick M\u00fchlethaler-Mottet. The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulation. Oncotarget. 2021. Pubmed<\/a><\/li>\n
  6. Vivancos Stalin L., Gualandi M., Schulte J.H., Renella R., Shakhova O., M\u00fchlethaler-Mottet A. Expression of the neuroblastoma-associated ALK-F1174L activating mutation during embryogenesis impairs the differentiation of neural crest progenitors in sympathetic ganglia. Front. Oncol. 2019. PubMed<\/a><\/li>\n
  7. M. Flahaut, N. Jauquier, N. Chevalier, K. Nardou, K. Balmas Bourloud, J.M. Joseph, D. Barras, C. Widmann, N. Gross, R. Renella and A. M\u00fchlethaler-Mottet. Aldehyde Dehydrogenase Activity Plays a Key Role in the Aggressive Phenotype of Neuroblastoma. BMC Cancer 2016. PubMed<\/a><\/li>\n
  8. M\u00fchlethaler-Mottet A, Liberman J, Ascen\u00e7\u00e3o K, Flahaut M, Balmas Bourloud K,\u00a0Yan P, Jauquier N, Gross N, Joseph JM. The CXCR4\/CXCR7\/CXCL12 Axis Is Involved in\u00a0a Secondary but Complex Control of Neuroblastoma Metastatic Cell Homing. PLoS\u00a0One 2015.\u00a0PubMed<\/a><\/li>\n
  9. Montavon G, Jauquier N, Coulon A, Peuchmaur M, Flahaut M, Bourloud KB, Yan P,\u00a0Delattre O, Sommer L, Joseph JM, Janoueix-Lerosey I, Gross N, M\u00fchlethaler-Mottet\u00a0A. Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations up regulate\u00a0Myc and initiate tumor formation in murine neural crest progenitor cells.
    \nOncotarget 2014.     PubMed<\/a><\/li>\n
  10. Liberman J, Sartelet H, Flahaut M, M\u00fchlethaler-Mottet A, Coulon A, Nyalendo C,\u00a0Vassal G, Joseph JM, Gross N. Involvement of the CXCR7\/CXCR4\/CXCL12 axis in the\u00a0malignant progression of human neuroblastoma. PLoS One 2012.\u00a0PubMed<\/a><\/li>\n
  11. Coulon A, Flahaut M, M\u00fchlethaler-Mottet A, Meier R, Liberman J,\u00a0Balmas-Bourloud K, Nardou K, Yan P, Tercier S, Joseph JM, Sommer L, Gross N.\u00a0Functional sphere profiling reveals the complexity of neuroblastoma\u00a0tumor-initiating cell model. Neoplasia 2011. \u00a0PubMed<\/a><\/li>\n
  12. M\u00fchlethaler-Mottet A, Flahaut M, Bourloud KB, Nardou K, Coulon A, Liberman J,\u00a0Thome M, Gross N. Individual caspase-10 isoforms play distinct and opposing roles\u00a0in the initiation of death receptor-mediated tumour cell apoptosis. Cell Death\u00a0Dis 2011. PubMed<\/a><\/li>\n<\/ol>\n
    \n

    Pediatric Hematology\u00a0Subgroup<\/strong>\u00a0(PI Dr Raffaele Renella MD PhD, all\u00a0prior affiliations: Williams Lab, Boston USA and Wood Lab, Oxford, UK<\/p>\n

      \n
    1. Altrock PM, Brendel C, Renella R, Orkin SH, Williams DA, Michor F. Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease. Am J Hematol. 2016 PubMed<\/a><\/li>\n
    2. Renella R. Clinically-oriented proteomic investigation of sickle cell disease:Opportunities and challenges. Proteomics Clin Appl. 2016. PubMed<\/a><\/li>\n
    3. Gavillet M, Martinod K, Renella R, Harris C, Shapiro NI, Wagner DD, Williams\u00a0DA. Flow cytometric assay for direct quantification of neutrophil extracellular\u00a0traps in blood samples. Am J Hematol 2015.\u00a0PubMed<\/a><\/li>\n
    4. Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson\u00a0AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI,\u00a0Williams DA. miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and\u00a0Hemoglobin F Induction. Mol Ther 2015.\u00a0PubMed<\/a><\/li>\n
    5. Renella R. Age-dependent pathophysiology of acute chest syndrome in children\u00a0with sickle cell disease. Am J Hematol 2015.\u00a0PubMed<\/a><\/li>\n
    6. Renella R, Schlehe JS, Selkoe DJ, Williams DA, LaVoie MJ. Genetic deletion of \u00a0the GATA1-regulated protein ?-synuclein reduces oxidative stress and nitric oxide\u00a0synthase levels in mature erythrocytes. Am J Hematol 2014. PubMed<\/a><\/li>\n
    7. Renella R, Carnevale J, Schneider KA, Hornick JL, Rana HQ, Janeway KA.\u00a0Exploring the association of succinate dehydrogenase complex mutations with\u00a0lymphoid malignancies. Fam Cancer. 2014.\u00a0PubMed<\/a><\/li>\n
    8. Renella R, Stickney C, Keswani M, Mancuso T, Casavant D, Ferguson M, Narla A. \u00a0Fulminant thrombotic microangiopathy in pediatrics: where diagnostic and\u00a0therapeutic dilemmas meet. Am J Hematol 2012. PubMed<\/a><\/li>\n
    9. Tolar J, Adair JE, Antoniou M, Bartholomae CC, Becker PS, Blazar BR, Bueren J,\u00a0Carroll T, Cavazzana-Calvo M, Clapp DW, Dalgleish R, Galy A, Gaspar HB, Hanenberg\u00a0H, Von Kalle C, Kiem HP, Lindeman D, Naldini L, Navarro S, Renella R, Rio P,\u00a0Sevilla J, Schmidt M, Verhoeyen E, Wagner JE, Williams DA, Thrasher AJ. Stem cell\u00a0gene therapy for fanconi anemia: report from the 1st international Fanconi anaemia\u00a0gene therapy working group meeting. Mol Ther 2011. PubMed<\/a><\/li>\n
    10. Renella R, Roberts NA, Brown JM, De Gobbi M, Bird LE, Hassanali T, Sharpe JA, Sloane-Stanley J, Ferguson DJ, Cordell J, Buckle VJ, Higgs DR, Wood WG. Codanin-1\u00a0mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha}\u00a0localization in erythroblasts. Blood 2011. PubMed<\/a><\/li>\n
    11. De Gobbi M, Garrick D, Lynch M, Vernimmen D, Hughes JR, Goardon N, Luc S,\u00a0Lower KM, Sloane-Stanley JA, Pina C, Soneji S, Renella R, Enver T, Taylor S,\u00a0Jacobsen SE, Vyas P, Gibbons RJ, Higgs DR. Generation of bivalent chromatin\u00a0domains during cell fate decisions. Epigenetics Chromatin 2011. PubMed<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

      Most recent publications (2010 – today)\u00a0 Neuroblastoma Subgroup (PI PD Dr Annick M\u00fchlethaler PhD) Sundaramoorthy S, Colombo DF, Sanalkumar R, Broye L, Balmas Bourloud K, Boulay G, Cironi L, Stamenkovic I, Renella R, Kuttler F, Turcatti G, Rivera MN,\u00a0M\u00fchlethaler-Mottet A,<\/p>\n","protected":false},"author":1001217,"featured_media":0,"parent":0,"menu_order":14,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-17","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/pages\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/users\/1001217"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":2,"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/pages\/17\/revisions"}],"predecessor-version":[{"id":569,"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/pages\/17\/revisions\/569"}],"wp:attachment":[{"href":"https:\/\/wp.unil.ch\/lhop\/wp-json\/wp\/v2\/media?parent=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}