{"id":178,"date":"2022-09-15T22:57:26","date_gmt":"2022-09-15T20:57:26","guid":{"rendered":"https:\/\/wp.unil.ch\/langletlab\/?page_id=178"},"modified":"2025-11-08T13:26:13","modified_gmt":"2025-11-08T12:26:13","slug":"research","status":"publish","type":"page","link":"https:\/\/wp.unil.ch\/langletlab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n

Hypothalamic control of energy balance<\/strong><\/h2>\n\n\n\n
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An adequate balance between energy intake and expenditure is essential for maintaining good health. To preserve this energy homeostasis, the brain engages in continuous dialogue with peripheral tissues to regulate both the energy entering the organism (through food intake) and the energy leaving it (through expenditure). To fulfill this role, the brain senses metabolic signals\u2014including hormones and nutrients\u2014that convey information about nutritional status and body energy stores, and responds through efferent regulatory pathways\u2014mainly via the endocrine and autonomic nervous systems\u2014to restore energy balance.<\/p>\n<\/div>\n\n\n\n

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Mobile<\/em>, Alexander Calder<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n
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Over the past decade, it has become evident that tanycytes\u2014specialized hypothalamic glial cells lining the floor of the third ventricle\u2014are ideally positioned to detect fluctuations in nutrient and hormone levels and to relay this metabolic information to neurons. Our research aims to elucidate the molecular mechanisms underlying the dialogue between tanycytes and neurons, the heterogeneity of these interactions, and the functional alterations induced by obesity.<\/p>\n\n\n\n

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The specific research directions of our laboratory include: <\/p>\n\n\n\n

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Project 1<\/h2>\n\n\n\n

Heterogeneity Among Tanycyte Populations and Their Functional Partnerships<\/strong><\/p>\n\n\n\n

What are the distinct subtypes of tanycytes? What functions do they perform? Which neuronal populations do they interact with?<\/p>\n\n\n\n

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Learn more ><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n
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Project 2<\/h2>\n\n\n\n

Molecular Signals Underlying Tanycyte\u2013Neural Cell Interactions<\/strong><\/p>\n\n\n\n

Which signals are released by tanycytes, which cells respond to them, and what functional outcomes result from these interactions?<\/p>\n\n\n\n

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Learn more ><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n
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Project 3<\/h2>\n\n\n\n

Subcellular Insights into Tanycyte Biology<\/strong><\/p>\n\n\n\n

How is the ultrastructure of tanycytes organized, and how does it support their functional roles?<\/p>\n\n\n\n

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Learn more ><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n
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Project 4<\/h2>\n\n\n\n

Tanycyte Contributions to Hypothalamic Development<\/strong><\/p>\n\n\n\n

When do tanycytes differentiate, and what role do they play in the formation of hypothalamic circuits?<\/p>\n\n\n\n

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Learn more ><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n
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\u201cAll truths are easy to understand once they are discovered; the point is to discover them.\u201d<\/p>Galileo Galilei<\/em><\/cite><\/blockquote><\/figure>\n\n\n\n

<\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

Hypothalamic control of energy balance An adequate balance between energy intake and expenditure is essential for maintaining good health. To preserve this energy homeostasis, the brain engages in…<\/p>\n","protected":false},"author":1002480,"featured_media":172,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-full-width-cover.php","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-178","page","type-page","status-publish","has-post-thumbnail"],"_links":{"self":[{"href":"https:\/\/wp.unil.ch\/langletlab\/wp-json\/wp\/v2\/pages\/178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.unil.ch\/langletlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.unil.ch\/langletlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/langletlab\/wp-json\/wp\/v2\/users\/1002480"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/langletlab\/wp-json\/wp\/v2\/comments?post=178"}],"version-history":[{"count":4,"href":"https:\/\/wp.unil.ch\/langletlab\/wp-json\/wp\/v2\/pages\/178\/revisions"}],"predecessor-version":[{"id":661,"href":"https:\/\/wp.unil.ch\/langletlab\/wp-json\/wp\/v2\/pages\/178\/revisions\/661"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/langletlab\/wp-json\/wp\/v2\/media\/172"}],"wp:attachment":[{"href":"https:\/\/wp.unil.ch\/langletlab\/wp-json\/wp\/v2\/media?parent=178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}