{"id":166,"date":"2021-03-19T22:50:27","date_gmt":"2021-03-19T21:50:27","guid":{"rendered":"https:\/\/wp.unil.ch\/kellenberger-lab\/?page_id=166"},"modified":"2026-01-06T10:09:56","modified_gmt":"2026-01-06T09:09:56","slug":"publications","status":"publish","type":"page","link":"https:\/\/wp.unil.ch\/kellenberger-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n
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A complete list of publications can be found in Pu<\/strong><\/a>bmed<\/a><\/strong> or on our official publication page<\/a> with links to accessible full text articles. This page here displays the latest published articles.<\/p>\n\n\n\n

2026<\/strong><\/p>\n\n\n\n

Acid-sensing ion channels: structure, function, pharmacology and clinical significance.<\/a> L. D. Rash and S. Kellenberger: Physiol Rev<\/em> (2026) doi:10.1152\/physrev.00002.2025<\/p>\n\n\n\n

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2025<\/strong><\/p>\n\n\n\n

The Concise Guide to PHARMACOLOGY 2025\/26: Ion channels.<\/a> Alexander SPH, Striessnig J, Gibb AJ, Mathie AA, Veale EL, Kelly E, Peach CJ, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Beech DJ, Biel M, Bill RM, Caceres AI, Catterall WA, Chua HC, Conner AC, Danahay H, Davies P, De Clerq K, Delling M, Di Virgilio F, Falzoni S, Fang W, Fenske S, Fortuny-Gomez A, Fountain S, Chandy GK, Ghovanloo MR, Goldstein SAN, Gosling M, Grimm C, Grissmer S, Ha K, Hales TG, Hammelmann V, Hanukoglu I, Hu M, Ijzerman AP, Jabba SV, Jarvis M, Jensen AA, Jordt SE, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Liu Q, Lynch JW, Manville RW, Meades J, Mehlfeld V, Nicke A, Offermanns S, Perez-Reyes E, Plant LD, Pless SA, Rash LD, Ren D, Rubaiy HN, Salman MM, Sieghart W, Sivilotti LG, Smart TG, Snutch TP, Tammaro P, Tian J, Trimmer JS, Van den Eynde C, Vergani P, Vriens J, Waxman SG, Wei AD, Winn BT, Wulff H, Xu H, Yang F, Yue L, Zhang X, and Zhu M. Br J Pharmacol <\/em>182 Suppl 1: S152-S241, 2025.<\/p>\n\n\n\n

Molecular mechanisms and hotspots of pH sensing in ASIC1a revealed by computational and functional analysis.<\/a> Olivier Bignucolo\u00b6<\/sup>, Oph\u00e9lie Molton\u00b6<\/sup>, Ivan Gautschi and Stephan Kellenberger: Commun Biol 10.1038\/s42003-025-09090-9. \u00b6<\/sup>, equal contribution<\/em><\/p>\n\n\n\n

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Case Report: Functional investigation of the \u03b3ENaC G532S mutation presenting as mild PHA-1B3.<\/a> E. Centonze, M. Girish, M.X. van Bemmelen, O. Staub, G. Subramaniam, and S. Kellenberger: Front. Med. Sec. Nephrology (2025) doi: 10.3389\/fmed.2025.1605057<\/p>\n<\/div>\n<\/div>\n\n\n\n

Functional properties of the gamma-ENaC-A635V mutation in a patient with severe hyponatremia.<\/a> M. Antoniadi, M. Bohnet, S. Kellenberger, D. I. Vitoratou, O. Fafoula, F. Mylona, S. Kostaridou, D. Palaiologou, A. Taliou and C. A. Stratakis: Hormones (Athens)<\/em> (2025) doi:10.1007\/s42000-025-00637-3<\/p>\n\n\n\n

De novo variants in LRRC8C resulting in constitutive channel activation cause a human multisystem disorder.<\/a> M. Quinodoz, S. Rutz, V. Peter, L. Garavelli, A. M. Innes, E. F. Lehmann, S. Kellenberger, Z. Peng, A. Barone, B. Campos-Xavier, S. Unger, C. Rivolta, R. Dutzler and A. Superti-Furga. EMBO J<\/em>, 44(2), 413-436 (2025) doi:10.1038\/s44318-024-00322-y<\/p>\n\n\n\n

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2024<\/strong><\/p>\n\n\n\n

Voltage-clamp fluorometry for advancing mechanistic understanding of ion channel mechanisms with a focus on acid-sensing ion channels. <\/a>Eleonora Centonze and Stephan Kellenberger. Biochem Soc Trans, <\/em>52(5):2167-2177. doi: 10.1042\/BST20240165.<\/p>\n\n\n\n

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Identification of the modulatory Ca2+<\/sup>-binding sites of acid-sensing ion channel 1a<\/a>. Oph\u00e9lie Molton, Olivier Bugnocolo, Stephan Kellenberger. Open biology <\/em>14: 240028, 2024. DOI: 10.1098\/rsob.240028<\/p>\n<\/div>\n<\/div>\n\n\n\n

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2023<\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n

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The Concise Guide to PHARMACOLOGY 2023\/24: Ion channels. <\/a>Alexander SPH, Mathie AA, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Caceres AI, Catterall WA, Conner AC, Davies P, De Clerq K, Delling M, Di Virgilio F, Falzoni S, Fenske S, Fortuny-Gomez A, Fountain S, George C, Goldstein SAN, Grimm C, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Hu M, Ijzerman AP, Jabba SV, Jarvis M, Jensen AA, Jordt SE, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Liu Q, Lynch JW, Meades J, Mehlfeld V, Nicke A, Offermanns S, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sieghart W, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yang F, Fang W, Yue L, Zhang X, and Zhu M. Br J Pharmacol <\/em>180 Suppl 2: S145-S222, 2023.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice.<\/a> Zhong Peng, Panos G. Ziros, Tomaz Martini, Xiao-Hui Liao, Ron Stoop, Samuel Refetoff, Urs Albrecht, Gerasimos P. Sykiotis, Stephan Kellenberger, 2023. Commun Biol 6, 857, doi.org\/10.1038\/s42003-023-05221-2<\/p>\n<\/div>\n<\/div>\n\n\n\n

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2022<\/strong><\/p>\n\n\n\n

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Calcium regulates acid-sensing ion channel 3 activation by competing with protons in the channel pore and at an allosteric binding site. <\/a>Roy S, Johner N, Trendafilov V, Gautschi I, Bignucolo O,Molton O, Bern\u00e8che S, Kellenberger S, 2022. Open Biol 12, 12, 220243, 10.1098\/rsob.220243<\/p>\n<\/div>\n<\/div>\n\n\n\n

Galvani Offset Potential and Constant-pH Simulations of Membrane Proteins<\/a>. Bignucolo O, Chipot C, Kellenberger S and Roux B, 2022. J Phys Chem B 2022, 126, 36, 6868\u20136877, 10.1021\/acs.jpcb.2c04593<\/p>\n\n\n\n

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Probing conformational changes during activation of ASIC1a by an optical tweezer and by methanethiosulfonate-based cross-linkers. <\/a>Vaithia A and Kellenberger S, 2022. Plos ONE e0270762. doi: 10.1371\/journal.pone.0270762<\/p>\n\n\n\n

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Kidney-Specific CAP1\/Prss8-Deficient Mice Maintain ENaC-Mediated Sodium Balance through an Aldosterone Independent Pathway<\/a>. Ehret E, Jager Y, Sergi C, Merillat AM, Peyrollaz T, Anand D, Wang Q, Ino F, Maillard M, Kellenberger S, Gautschi I, Szabo R, Bugge TH, Vogel LK, Hummler E, Frateschi S, 2022. Int J Mol Sci 23 (12). doi:10.3390\/ijms23126745<\/p>\n\n\n\n

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2021<\/strong><\/p>\n\n\n\n

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THE CONCISE GUIDE TO PHARMACOLOGY 2021\/22: Ion channels. <\/a>Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Catterall WA, Conner AC, Davies P, Delling M, Virgilio FD, Falzoni S, Fenske S, George C, Goldstein SAN, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Jarvis M, Jensen AA, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Lynch JW, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yue L, Zhang X, Zhu M. Br J Pharmacol. <\/em>2021;178 Suppl 1:S157-S245.<\/p>\n\n\n\n

Changes in H+<\/sup>, K+<\/sup> and Ca2+<\/sup> concentrations, as observed in seizures, induce action potential signaling in cortical neurons by a mechanism that depends partially on ASICs.<\/a> Alijevic Omar*, Peng Zhong*, Kellenberger Stephan, 2021. Frontiers in Cellular Neurosciences 15, 732869. (*, these authors contributed equally and share first authorship<\/em>)<\/p>\n\n\n\n

Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate<\/a>. Vullo Sabrina, Ambrosio Nicolas, Kucera Jan P., Bignucolo Olivier, Kellenberger Stephan. eLife, 10. DOI: 10.7554\/eLife.66488.<\/p>\n\n\n\n

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Hydrogen sulfide upregulates acid-sensing ion channels via the MAPK-Erk1\/2 signaling pathway.<\/a> Peng Zhong, Kellenberger Stephan, 2021. Function, 2 (2), zqab007.<\/p>\n\n\n\n

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2020<\/strong><\/p>\n\n\n\n

Structural and Functional Analysis of Gly212 Mutants Reveals the Importance of Intersubunit Interactions in ASIC1a Channel Function. <\/a>Bignucolo Olivier, Vullo Sabrina, Ambrosio Nicolas, Gautschi Ivan, Kellenberger Stephan, 2020. Frontiers in Molecular Biosciences, 7.<\/p>\n\n\n\n

Slowing of the Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons.<\/a> Alijevic Omar, Bignucolo Olivier, Hichri Echrak, Peng Zhong, Kucera Jan P., Kellenberger Stephan, 2020. Frontiers in Cellular Neuroscience, 14.<\/p>\n\n\n\n

Acid-Sensing Ion Channels. <\/a>Haerteis Silke, Kellenberger Stephan, 2020. In Encyclopedia of molecular pharmacology, Stefan Offermanns and Walther Rosenthal.<\/p>\n\n\n\n

Epithelial Na+<\/sup> Channel. <\/a>Haerteis Silke, Kelllenberger Stephan, 2020. In Encyclopedia of molecular pharmacology, Stefan Offermanns and Walther Rosenthal.<\/p>\n\n\n\n

A molecular view of the function and pharmacology of acid-sensing ion channels. <\/a>Vullo S., Kellenberger S., 2020. Pharmacological research, 154 p. 104166.<\/p>\n\n\n\n

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2019<\/strong><\/p>\n\n\n\n

THE CONCISE GUIDE TO PHARMACOLOGY 2019\/20: Ion channels. <\/a>Alexander Stephen P H, Mathie Alistair, Peters John A, Veale Emma L, Striessnig J\u00f6rg, Kelly Eamonn, Armstrong Jane F, Faccenda Elena, Harding Simon D, Pawson Adam J et al., 2019. British Journal of Pharmacology, 176 (S1).<\/p>\n\n\n\n

Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides. <\/a>Bargeton B., Iwaszkiewicz J., Bonifacio G., Roy S., Zoete V., Kellenberger S., 2019. Scientific reports, 9 (1) p. 2599.<\/p>\n\n\n\n

Accelerated Current Decay Kinetics of a Rare Human Acid-Sensing ion Channel 1a Variant That Is Used in Many Studies as Wild Type.<\/a> Vaithia A., Vullo S., Peng Z., Alijevic O., Kellenberger S., 2019. Frontiers in molecular neuroscience, 12 p. 133.<\/p>\n\n\n\n

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2018<\/strong><\/p>\n\n\n\n

Heteroarylguanidines as Allosteric Modulators of ASIC1a and ASIC3 Channels.<\/a> Alijevic O., Hammoud H., Vaithia A., Trendafilov V., Bollenbach M., Schmitt M., Bihel F., Kellenberger S., 2018. ACS chemical neuroscience, 9 (6) pp. 1357-1365.<\/p>\n\n\n\n

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2017<\/strong><\/p>\n\n\n\n

THE CONCISE GUIDE TO PHARMACOLOGY 2017\/18: Overview. <\/a>Alexander S.P., Kelly E., Marrion N.V., Peters J.A., Faccenda E., Harding S.D., Pawson A.J., Sharman J.L., Southan C., Buneman O.P. et al., 2017. British journal of pharmacology, 174 Suppl 1 pp. S1-S16.<\/p>\n\n\n\n

Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating. <\/a>Vullo S., Bonifacio G., Roy S., Johner N., Bern\u00e8che S., Kellenberger S., 2017\/04\/04. Proceedings of the National Academy of Sciences of the United States of America, 114 (14) pp. 3768-3773.<\/p>\n\n\n\n

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For earlier publications by our group please see the complete official publication page<\/a> with links to accessible full text articles (follow the link and choose “Publications”). <\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

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