{"id":653,"date":"2013-04-22T15:32:21","date_gmt":"2013-04-22T13:32:21","guid":{"rendered":"http:\/\/wp.unil.ch\/hardtkelab\/?p=653"},"modified":"2013-04-22T16:17:38","modified_gmt":"2013-04-22T14:17:38","slug":"yes-the-cop1-ring-finger-is-important-for-function","status":"publish","type":"post","link":"https:\/\/wp.unil.ch\/hardtkelab\/2013\/04\/yes-the-cop1-ring-finger-is-important-for-function\/","title":{"rendered":"Yes, the COP1 RING finger is important for function!"},"content":{"rendered":"<figure id=\"attachment_655\" aria-describedby=\"caption-attachment-655\" style=\"width: 166px\" class=\"wp-caption alignright\"><a href=\"https:\/\/wp.unil.ch\/hardtkelab\/files\/2013\/04\/cop1C52F.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-655\" alt=\"An Arabidopsis seedling homozygous for the COP1 C52 F amino acid change.\" src=\"https:\/\/wp.unil.ch\/hardtkelab\/files\/2013\/04\/cop1C52F-166x300.jpg\" width=\"166\" height=\"300\" srcset=\"https:\/\/wp.unil.ch\/hardtkelab\/files\/2013\/04\/cop1C52F-166x300.jpg 166w, https:\/\/wp.unil.ch\/hardtkelab\/files\/2013\/04\/cop1C52F.jpg 355w\" sizes=\"auto, (max-width: 166px) 100vw, 166px\" \/><\/a><figcaption id=\"caption-attachment-655\" class=\"wp-caption-text\">An Arabidopsis seedling homozygous for the COP1 C52 F amino acid change.<\/figcaption><\/figure>\n<p>From our graveyard of unpublished but interesting results: an Arabidopsis\u00a0<em>cop1<\/em>\u00a0mutant allele isolated in our lab carries a G to T base change that results in a C52F amino acid change. Plants homozygous for this mutation in the COP1 RING finger display a fully penetrant strong constitutive photomorphogenic phenotype (see illustration).<\/p>\n<p>We had to solve a genetic riddle to find out that we obtained this allele as a spontaneous mutation that occurred in an already triple mutant background. It cost us lots of energy (i.e. time and some money), but it was fun solving the riddle. I&#8217;m afraid however that we won&#8217;t find the energy to publish this in a conventional way. So be careful: the above is true, but not peer-reviewed \ud83d\ude09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>From our graveyard of unpublished but interesting results: an Arabidopsis\u00a0cop1\u00a0mutant allele isolated in our lab carries a G to T base change that results in a C52F amino acid change. &hellip; <\/p>\n","protected":false},"author":1001,"featured_media":655,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"categories":[54466],"tags":[52949,54495,54496,54497,54498],"class_list":{"0":"post-653","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-hardtke-lab-generic","8":"tag-arabidopsis","9":"tag-cop1","10":"tag-mutation","11":"tag-photomorphogenesis","12":"tag-ring-finger"},"_links":{"self":[{"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/posts\/653","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/users\/1001"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/comments?post=653"}],"version-history":[{"count":0,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/posts\/653\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/media\/655"}],"wp:attachment":[{"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/media?parent=653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/categories?post=653"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/tags?post=653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}