{"id":2282,"date":"2025-04-24T09:07:09","date_gmt":"2025-04-24T07:07:09","guid":{"rendered":"https:\/\/wp.unil.ch\/hardtkelab\/?p=2282"},"modified":"2025-04-24T11:17:47","modified_gmt":"2025-04-24T09:17:47","slug":"somethings-incoherent-here","status":"publish","type":"post","link":"https:\/\/wp.unil.ch\/hardtkelab\/2025\/04\/somethings-incoherent-here\/","title":{"rendered":"Something&#8217;s incoherent here"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">&#8230;and it&#8217;s a feedforward loop! Qian&#8217;s discovery of a nontranscriptional incoherent feedforward loop in a receptor kinase signaling pathway has now been published in the <em><a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2420575122\">Proceedings of the National Academy of Sciences, U.S.A<\/a><\/em>. Starting from proteomics experiments performed by former postdoc Yeon Hee Kang, we found that the enigmatic MAKR5 protein is an amplifier of CLE45-BAM3 signaling whose abundance is itself regulated via CLE45-BAM3-dependent <em>MAKR5<\/em> mRNA translation in a, well, incoherent feedforward loop.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8230;and it&#8217;s a feedforward loop! Qian&#8217;s discovery of a nontranscriptional incoherent feedforward loop in a receptor kinase signaling pathway has now been published in the Proceedings of the National Academy &hellip; <\/p>\n","protected":false},"author":1001,"featured_media":2284,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"footnotes":""},"categories":[54466],"tags":[52949,54493,54494,54659,54602,54660,54603,54633],"class_list":["post-2282","post","type-post","status-publish","format-standard","has-post-thumbnail","category-hardtke-lab-generic","tag-arabidopsis","tag-bam3","tag-cle45","tag-incoherent-feedforward-loop","tag-makr5","tag-mrna-translation","tag-protophloem","tag-receptor-kinase"],"_links":{"self":[{"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/posts\/2282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/users\/1001"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/comments?post=2282"}],"version-history":[{"count":3,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/posts\/2282\/revisions"}],"predecessor-version":[{"id":2289,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/posts\/2282\/revisions\/2289"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/media\/2284"}],"wp:attachment":[{"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/media?parent=2282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/categories?post=2282"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/tags?post=2282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}