{"id":2104,"date":"2023-02-15T16:10:13","date_gmt":"2023-02-15T15:10:13","guid":{"rendered":"https:\/\/wp.unil.ch\/hardtkelab\/?p=2104"},"modified":"2023-05-31T07:50:15","modified_gmt":"2023-05-31T05:50:15","slug":"double-trouble-cle-peptides","status":"publish","type":"post","link":"https:\/\/wp.unil.ch\/hardtkelab\/2023\/02\/double-trouble-cle-peptides\/","title":{"rendered":"Double trouble CLE peptide signaling"},"content":{"rendered":"\n<p>Our latest nearly-back-to-back outputs in<a rel=\"noreferrer noopener\" href=\"https:\/\/www.cell.com\/current-biology\/pdf\/S0960-9822(22)01993-5.pdf\" target=\"_blank\"> <em>Current Biology<\/em><\/a> and <a rel=\"noreferrer noopener\" href=\"https:\/\/www.nature.com\/articles\/s41467-023-36200-0\" data-type=\"URL\" data-id=\"https:\/\/www.nature.com\/articles\/s41467-023-36200-0\" target=\"_blank\"><em>Nature Communications<\/em><\/a>: for years we have known that autocrine CLE45 peptide signaling via its receptor BAM3 suppresses protophloem sieve element differentiation. What remained unclear was, how ? And, how do developing protophloem sieve elements eventually evade this inhibitory signal?<\/p>\n\n\n\n<p>The answers are in our two latest papers: <a rel=\"noreferrer noopener\" href=\"https:\/\/www.nature.com\/articles\/s41467-023-36200-0\" target=\"_blank\">CLE45 peptide signaling directly interferes with auxin efflux regulation in the protophloem<\/a>, the latter being essential to guide the differentiation process. And: <a rel=\"noreferrer noopener\" href=\"https:\/\/www.cell.com\/current-biology\/pdf\/S0960-9822(22)01993-5.pdf\" target=\"_blank\">developing protophloem sieve elements evade the inhibitory CLE45 signal by alkalanizing their apoplast.<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our latest nearly-back-to-back outputs in Current Biology and Nature Communications: for years we have known that autocrine CLE45 peptide signaling via its receptor BAM3 suppresses protophloem sieve element differentiation. What &hellip; <\/p>\n","protected":false},"author":1001,"featured_media":2105,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"categories":[54466],"tags":[52949,54501,54598,54653,54541],"class_list":{"0":"post-2104","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-hardtke-lab-generic","8":"tag-arabidopsis","9":"tag-auxin","10":"tag-cle","11":"tag-ph","12":"tag-phloem"},"_links":{"self":[{"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/posts\/2104","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/users\/1001"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/comments?post=2104"}],"version-history":[{"count":0,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/posts\/2104\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/media\/2105"}],"wp:attachment":[{"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/media?parent=2104"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/categories?post=2104"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.unil.ch\/hardtkelab\/wp-json\/wp\/v2\/tags?post=2104"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}