{"id":22,"date":"2016-09-07T11:09:11","date_gmt":"2016-09-07T09:09:11","guid":{"rendered":"http:\/\/wp.unil.ch\/gruberlab\/?page_id=22"},"modified":"2025-10-23T09:45:16","modified_gmt":"2025-10-23T07:45:16","slug":"info","status":"publish","type":"page","link":"https:\/\/wp.unil.ch\/gruberlab\/","title":{"rendered":"Genome Integrity &amp; Nucleic Acid Immunity"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/wp.unil.ch\/gruberlab\/\"><img alt=\"\" loading=\"lazy\" decoding=\"async\" width=\"828\" height=\"681\" src=\"https:\/\/wp.unil.ch\/gruberlab\/files\/2023\/09\/logo_GruberLab_transparent.png\" alt=\"\" class=\"wp-image-1579\" style=\"width:148px;height:115px\" srcset=\"https:\/\/wp.unil.ch\/gruberlab\/files\/2023\/09\/logo_GruberLab_transparent.png 828w, https:\/\/wp.unil.ch\/gruberlab\/files\/2023\/09\/logo_GruberLab_transparent-300x247.png 300w, https:\/\/wp.unil.ch\/gruberlab\/files\/2023\/09\/logo_GruberLab_transparent-768x632.png 768w\" sizes=\"auto, (max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px\" \/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>We aim to understand how SMC-based molecular machines act on DNA to preserve the integrity of genetic information\u2014both by maintaining chromosomal DNA and by defending against invasive elements such as viruses and plasmids.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>How is non-self DNA recognized and eliminated?<\/li>\n\n\n\n<li>How are chromosomes segregated during cell division?<\/li>\n\n\n\n<li>How is DNA damage repaired?<\/li>\n\n\n\n<li>How are genomes organized in space &amp; time?<\/li>\n<\/ul>\n\n\n\n<p>We are part of the Department of Fundamental Microbiology (<a href=\"https:\/\/bsky.app\/profile\/dmf-unil.bsky.social\">\u202a@dmf-unil.bsky.social\u202c<\/a>) at the Faculty of Biology and Medicine, the University of Lausanne. Find out <a href=\"https:\/\/www.unil.ch\/gruberlab\/members\">who<\/a> we are and <a href=\"https:\/\/www.unil.ch\/gruberlab\/research\">what<\/a> we do. Follow us <a href=\"https:\/\/bsky.app\/profile\/gruberlab.bsky.social\">@GruberLab.bsky.social.<\/a><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><a href=\"https:\/\/wp.unil.ch\/gruberlab\/files\/2019\/12\/11023_orig.png\" rel=\"https:\/\/cellimagelibrary.org\/images\/11023\"><img alt=\"\" loading=\"lazy\" decoding=\"async\" width=\"882\" height=\"1252\" src=\"https:\/\/wp.unil.ch\/gruberlab\/files\/2019\/12\/11023_orig.png\" alt=\"\" class=\"wp-image-1115\" srcset=\"https:\/\/wp.unil.ch\/gruberlab\/files\/2019\/12\/11023_orig.png 882w, https:\/\/wp.unil.ch\/gruberlab\/files\/2019\/12\/11023_orig-211x300.png 211w, https:\/\/wp.unil.ch\/gruberlab\/files\/2019\/12\/11023_orig-721x1024.png 721w, https:\/\/wp.unil.ch\/gruberlab\/files\/2019\/12\/11023_orig-768x1090.png 768w\" sizes=\"auto, (max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px\" \/><\/a><figcaption class=\"wp-element-caption\">Electron micrograph showing part of a decondensed mitotic chromosome. <a href=\"https:\/\/cellimagelibrary.org\/images\/11023\">CIL: 11023<\/a><\/figcaption><\/figure>\n<\/div>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We aim to understand how SMC-based molecular machines act on DNA to preserve the integrity of genetic information\u2014both by maintaining chromosomal DNA and by defending against invasive elements such as viruses and plasmids. We are part of the Department of Fundamental Microbiology (\u202a@dmf-unil.bsky.social\u202c) at the Faculty of Biology and Medicine, the University of Lausanne. Find &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/wp.unil.ch\/gruberlab\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Genome Integrity &amp; Nucleic Acid Immunity&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1001367,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"DNA Integrity & Immunity","_seopress_robots_index":"","footnotes":""},"class_list":["post-22","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/wp.unil.ch\/gruberlab\/wp-json\/wp\/v2\/pages\/22","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.unil.ch\/gruberlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.unil.ch\/gruberlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/gruberlab\/wp-json\/wp\/v2\/users\/1001367"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/gruberlab\/wp-json\/wp\/v2\/comments?post=22"}],"version-history":[{"count":5,"href":"https:\/\/wp.unil.ch\/gruberlab\/wp-json\/wp\/v2\/pages\/22\/revisions"}],"predecessor-version":[{"id":1811,"href":"https:\/\/wp.unil.ch\/gruberlab\/wp-json\/wp\/v2\/pages\/22\/revisions\/1811"}],"wp:attachment":[{"href":"https:\/\/wp.unil.ch\/gruberlab\/wp-json\/wp\/v2\/media?parent=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}