{"id":1166,"date":"2014-05-02T09:31:00","date_gmt":"2014-05-02T07:31:00","guid":{"rendered":"http:\/\/wp.unil.ch\/esspace\/?p=1166"},"modified":"2014-05-07T11:22:40","modified_gmt":"2014-05-07T09:22:40","slug":"lea-bertholet","status":"publish","type":"post","link":"https:\/\/wp.unil.ch\/esspace\/2014\/05\/lea-bertholet\/","title":{"rendered":"L\u00e9a Bertholet"},"content":{"rendered":"<p><strong>Recherche translationnelle en neurosciences psychiatriques: de l&rsquo;animal mod\u00e8le de schizophr\u00e9nie \u00e0 la d\u00e9tection d&rsquo;une d\u00e9sorientation spatiale, pratique ou symbolique chez des patients <\/strong><!--more--><\/p>\n<p><em>L\u00e9a Bertholet a obtenu son Master en Psychologie exp\u00e9rimentale \u00e0 l\u2019UNIL en 2008. Depuis, elle a travaill\u00e9 en tant qu\u2019assistante dipl\u00f4m\u00e9e \u00e0 l\u2019Institut de psychologie et a effectu\u00e9 une th\u00e8se en Neurosciences sous la dir. de la Prof. Fran\u00e7oise Schenk au sein de l\u2019unit\u00e9 de recherche sur la neuro\u00e9thologie des fonctions cognitives (Centre de Neurosciences Psychiatriques).<\/em><\/p>\n<p>La mod\u00e9lisation, chez l\u2019animal, de maladies psychiatriques telles que la schizophr\u00e9nie repose sur diff\u00e9rentes d\u00e9marches visant \u00e0 induire des perturbations c\u00e9r\u00e9brales similaires \u00e0 celles observ\u00e9es dans la maladie. Nous avons cherch\u00e9 \u00e0 \u00e9tudier chez le rat les effets d&rsquo;une diminution (50%) transitoire en glutathion (GSH) durant son d\u00e9veloppement (PND 5 \u00e0 PND 16) \u00e0 partir de l\u2019implication, chez des adultes, des cons\u00e9quences de cette perturbation dans des m\u00e9canismes fondamentaux de traitement de l\u2019information sensorielle. Cette th\u00e8se \u00e9value et documente les d\u00e9ficits de comp\u00e9tences de navigation spatiale dans ce mod\u00e8le.<\/p>\n<p>Chez les rats ayant subi un d\u00e9ficit en GSH, nous avons mis en \u00e9vidence des effets comportementaux \u00e0 partir de l\u2019identification de diff\u00e9rences particuli\u00e8res dans des t\u00e2ches d\u2019orientation: des difficult\u00e9s \u00e0 \u00e9laborer une repr\u00e9sentation globale de l\u2019environnement dans lequel ces animaux se d\u00e9placent, difficult\u00e9s compens\u00e9es par une attention sp\u00e9cifique aux d\u00e9tails visuels le composant. Cette strat\u00e9gie r\u00e9active compensatoire est efficace lorsque les conditions permettent un ajustement continu aux rep\u00e8res visuels environnementaux. Elle ne permet cependant pas des pr\u00e9dictions et des attentes sur ce qui devrait \u00eatre rencontr\u00e9 et per\u00e7u dans une certaine direction, d\u00e8s qu\u2019une partie des informations visuelles famili\u00e8res dispara\u00eet. Il faudrait pour cela une capacit\u00e9 fond\u00e9e sur <strong>une repr\u00e9sentation abstraite, \u00e0 distance des modalit\u00e9s sensorielles qui en ont permis son \u00e9laboration<\/strong>. Notre th\u00e8se soutient ainsi que les d\u00e9ficits, suppos\u00e9s participer \u00e0 l\u2019\u00e9mergence de certains sympt\u00f4mes de la maladie, auraient \u00e9galement des cons\u00e9quences sur l\u2019\u00e9laboration de la repr\u00e9sentation spatiale n\u00e9cessaire \u00e0 des capacit\u00e9s d\u2019orientation effectives et symboliques.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recherche translationnelle en neurosciences psychiatriques: de l&rsquo;animal mod\u00e8le de schizophr\u00e9nie \u00e0 la d\u00e9tection d&rsquo;une d\u00e9sorientation spatiale, pratique ou symbolique chez des patients<\/p>\n","protected":false},"author":163,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_uag_custom_page_level_css":"","_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[19459,19451],"tags":[],"class_list":["post-1166","post","type-post","status-publish","format-standard","category-numero-6","category-theses"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"hitmag-landscape":false,"hitmag-featured":false,"hitmag-grid":false,"hitmag-list":false,"hitmag-thumbnail":false,"gform-image-choice-sm":false,"gform-image-choice-md":false,"gform-image-choice-lg":false,"mailpoet_newsletter_max":false},"uagb_author_info":{"display_name":"sschlat1","author_link":"https:\/\/wp.unil.ch\/esspace\/author\/sschlat1\/"},"uagb_comment_info":0,"uagb_excerpt":"Recherche translationnelle en neurosciences psychiatriques: de l&rsquo;animal mod\u00e8le de schizophr\u00e9nie \u00e0 la d\u00e9tection d&rsquo;une d\u00e9sorientation spatiale, pratique ou symbolique chez des patients","_links":{"self":[{"href":"https:\/\/wp.unil.ch\/esspace\/wp-json\/wp\/v2\/posts\/1166","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.unil.ch\/esspace\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.unil.ch\/esspace\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/esspace\/wp-json\/wp\/v2\/users\/163"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.unil.ch\/esspace\/wp-json\/wp\/v2\/comments?post=1166"}],"version-history":[{"count":0,"href":"https:\/\/wp.unil.ch\/esspace\/wp-json\/wp\/v2\/posts\/1166\/revisions"}],"wp:attachment":[{"href":"https:\/\/wp.unil.ch\/esspace\/wp-json\/wp\/v2\/media?parent=1166"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.unil.ch\/esspace\/wp-json\/wp\/v2\/categories?post=1166"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.unil.ch\/esspace\/wp-json\/wp\/v2\/tags?post=1166"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}