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October 2022
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DBC SEMINARS

Lausanne Oncology CARMONA lab

with Dr. Santiago Carmona

Group leader Cancer Systems Immunology

Département d'oncologie UNIL CHUV
Ludwig Institute for Cancer Research

More information about Dr. Carmona


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Date : Thursday October 13 – 12h15

Location : Auditoire A – Génopode

Zoom Link – Password : HPC_DBC

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Host : Prof. Nicolas Salamin

"Tackling the immune cell identification crisis in the single-cell omics era"

Abstract:
Single-cell transcriptomics has emerged as a leading assay to unbiasedly identify cell populations. However, it is becoming increasingly challenging to associate equivalent immune cell populations across studies and systems to find consensus definitions.
In this talk I will discuss the computational methods we have developed to tackle this problem, highlighting applications to characterize immune responses in the context of cancer, viral infection, and immunotherapies. In particular, we propose a combination of marker-based and reference mapping-based classification using cell type- and context-specific curated single-cell maps. These tools will likely play a critical role to exploit the full potential of community single-cell data to guide new discoveries.

BIO :
Santiago Carmona obtained his PhD in Biotechnology in 2015 from the University of San Martin, in Buenos Aires, Argentina, where he pioneered the application of high-density peptide microarrays to characterize pathogen-specific antibody repertoires, leading to improved diagnostics for Chagas disease, a devastating endemic disease in South America. Part of his doctoral studies were conducted at the Technical University of Denmark, and at La Jolla Institute (USA) as a Fulbright fellow.
In 2016, he joined the University of Lausanne as a postdoc in Prof. Gfeller's lab to study immune cell diversity in Zebrafish by single-cell genomics, leading to the identification of a natural killer-like cell population and new insights into the evolution of vertebrates lymphocytes.
In 2019, Santiago established his group at the Ludwig Institute for Cancer Research, University of Lausanne, and part of the Swiss Institute of Bioinformatics.
Working at the crossroads of data science, single-cell omics technologies and cancer immunology, his team develops and applies computational methods to understand how our immune system responds to cancer, and to identify new therapeutic targets and disease biomarkers.

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