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DBC News is a monthly publication that seeks to inform first and foremost faculty members, researchers and students. It also reaches out to a wider community - Department of Computational Biology partners, visiting faculty and friends.
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Alongside the Department's website it is a complementary means of keeping abreast of the Department's rich and diversified scientific activities - visiting faculty, exceptional conferences, publications, awards, appointments, calls for papers and research, ...
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The whole DBC extends the warmest of welcomes to new members.
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Christian studied Biochemistry at the University of Zurich. His PhD research focused on using NMR spectroscopy to investigate picosecond-to-nanosecond dynamics in a GPCR and to trace the evolution of a metalloprotein in snails. Following his PhD, he worked as a scientific staff member at the Zurich Water Works.
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Many thanks for your contribution to the DBC throughout these years. We wish you great success in your future endeavours.
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Alexander Warwick Vesztrocy
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Genetic study challenges theory of Easter Island ecocide
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The population of Easter Island in the South Pacific did not collapse in the 17th century as a result of human-induced “environmental suicide” and over-exploitation of resources. This is the conclusion of an international study involving two researchers from the DBC, Anna-Sapfo Malaspinas and Bárbara Sousa da Mota.
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2nd Alma Dal Co memorial symposium - November 15th
Building on last year's symposium, also this year we will commemorate our late colleague and friend Alma Dal Co, who was a professor at the Department of Computational Biology (DBC) of UNIL.
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Evolutionary biologist - University of Lyon (France)
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How do scientists find genes using computers?
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Where to find your DNA in the Genes?
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All the events of the APNS here
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What follows is a small sampling of recently published research across the department — for a more complete list of publications, visit PubMed. If there is a paper you would like to see highlighted in the next issue of the newsletter, please email us.
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The pleiotropic spectrum of proximal 16p11.2 CNVs - With Chiara Auwerx, Zoltán Kutalik -We comprehensively reviewed the pleiotropy associated with 16p11.2 BP4-5 rearrangements to shine light on its full phenotypic spectrum, its phenotypic heterogeneity. We have also systematically contrasted findings obtained from clinical versus population-based cohorts.
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Widespread natural selection on metabolite levels in humans - With Yanina Timasheva, Kaido Lepik, Zoltán Kutalik -- Leveraging genome-wide association data, we estimated the strength of stabilising selection acting on 97 plasma metabolite levels and found strong evidence of this for 15 of them. Mendelian randomization analysis showed that metabolites under stronger stabilizing selection display larger effects on a range of clinically relevant complex traits.
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Phenotypic and Genetic Characteristics of Retinal Vascular Parameters and their Association with Diseases - With Sofía Ortín Vela, Michael Johannes Beyeler, Olga Trofimova, Mattia Tomasoni, Ilaria Iuliani, David Presby, Sven Bergmann --We extracted 17 different morphological vascular phenotypes, such as vessel diameter and tortuosity, for close to 72k UK Biobank subjects and performed Genome-Wide Association Studies of these phenotypes to estimate their heritabilities to be up to 25%, and genetic cross-phenotype correlations largely mirroring the corresponding phenotypic correlations.
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Towards predicting the geographical origin of ancient samples with metagenomic data - With Davide Bozzi , Samuel Neuenschwander , Diana Ivette Cruz Dávalos, Bárbara Sousa da Mota, J Víctor Moreno-Mayar, Anna-Sapfo Malaspinas -- Tracing the origin of human skeletal remains stored in museum collections can be challenging, especially when key information about the sampling location is missing. We show that the metagenome obtained from ancient individual samples, enriched in soil-derived microorganism, yields a geographic signal that can be exploited to extract information about the individual's origin.
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Are you an alumnus or former employee of the department? Email us your news and updates to include in an upcoming newsletter!
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