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April 2021

Newsletter

DBC News is a monthly publication that seeks to inform first and foremost faculty members, researchers and students. It also reaches out to a wider community - Department of Computational Biology partners, visiting faculty and friends.

Alongside the Department's website it is a complementary means of keeping abreast of the Department's rich and diversified scientific activities - visiting faculty, exceptional conferences, publications, awards, appointments, calls for papers and research, ...
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DBC WELCOME

The whole DBC extends the warmest of welcomes to new members.
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Adriaan van der Graaf
Post-doctoral student, Group Kutalik

My name is Adriaan van der Graaf and I'm a Dutch molecular biologist who has taken a keen interest in statistical approaches to biological data.

During my bachelor molecular biology I found it really hard to grasp how statistical inference was done based on the data that was being produced in the lab.
So I opted to do a master program that was tailored to learning about statistics and inference from large biological data.During my masters I ended up doing an internship at the Genetics department in Groningen, learning about how we can best predict polygenic scores for celiac disease.
After this internship I was offered a PhD in the lab of Cisca Wijmenga under the direct supervision of Serena Sanna, working on how best to prioritize celiac disease genes for follow up in the lab.

I learned quickly that I was very interested in causal inference and how we can infer causality based on just observational data.

In parallel to the celiac disease work, we developed a new Mendelian randomization technique called MR-link that can better identify causal gene expression in a GWAS locus.
During my future work at the Kutalik group, I hope to be able to identify causal relationships that can be integrated into causal networks, to better understand how causal factors influence traits like human disease.

In my spare time, I like to do bouldering, and during the corona times, I've taken up a 3d printing as a hobby, making a pen plotter and designing and building my own lamps.
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