Selfish Genetic Elements and Within-Organism Conflicts

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Ellen Clarke’s research explores the metaphysics and epistemology of biological science. It asks questions such as What biological objects are there and what sorts of things are they? Where does each end and another begin? How can we explain how they came into being? and more.  

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Daven Presgraves investigates the evolution of the selfish Segregation Distorter (SD) complex in the Drosophila genus. His lab uses molecular and evolutionary genetics to identify the role of selfish genetic elements in chromosome evolution, hybrid incompatibilities, and speciation.

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Anna Lindholm investigates the consequences of a male meiotic drive, the t-haplotype, in mice. Specifically, her lab focuses on the behavioural, evolutionary and ecological impact of this selfish genetic elements.

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Takashi Akera uses cellular imaging techniques and molecular biology to investigate the causes and consequences of female meiotic drive in mice. Specifically, his research group focuses on the cellular and molecular mechanisms underlying centromere drive.

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Tatiana Dimitriu studies bacteria and mobile genetic elements (MGEs), focusing on antimicrobial resistance (AMR) transmission. Her research explores how bacterial defence systems and competing plasmids impact AMR spread. By understanding these mechanisms, her work aims to propose treatments to reduce AMR prevalence.