Tissue lipid content

Obesity and adipose tissue dysfunction are associated with the accumulation of lipids in non-adipose tissues. The so-called ectopic fat deposition in liver (hepatic steatosis) and muscle (intramyocellular lipids) often associates with insulin resistance.

Lipids are extracted by the Folch method. Parameters that can be measured include :

  • Triglycerides, Total cholesterol, Free fatty acids.
  • Optional: Cholesterol esters (with an additional purification step).

Price: Please contact us.

See also: Body lipid content.

References:

Minehira, K., Young, SG., Villanueva, CJ., Yetukuri, L., Oresic, M., Hellerstein, MK., Farese, RV. Jr, Horton, JD., Preitner, F., Thorens, B., and Tappy, L. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res. 49(9):2038-44, 2008