Elevated blood levels of triglycerides (hypertriglyceridemia) is a medical condition which, as a cluster with other metabolic risk factors (the metabolic syndrome), predisposes to cardiovascular diseases, stroke and diabetes.
The liver plays a central role in the various aspects of lipid metabolism, including free fatty acid (FFA) de novo synthesis, FFA oxydation, and lipid export through the synthesis of Very Low Density Lipoproteins (VLDL). Triglycerides incorporated into VLDL are synthetized through hepatic esterification of both circulating endogenous FFAs (released by adipose tissue lipolysis) and FFAs synthetized de novo in the liver.
The hepatic VLDL-TG production test assesses whether hypertriglyceridemia is associated with excessive hepatic triglyceride production.
A minimum of 8 mice per group is required.
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