Publications for which MEF services were used (with or without authorship)

44. Lai Q, Giralt A, Le May C, Zhang L, Cariou B, Denechaud PD, Fajas L. E2F1 inhibits circulating cholesterol clearance by regulating Pcsk9 expression in the liver. JCI Insight. 2017 May 18;2(10). pii: 89729. doi: 10.1172/jci.insight.89729.

43. Somm E, Henry H, Bruce SJ, Aeby S, Rosikiewicz M, Sykiotis GP, Asrih M, Jornayvaz FR, Denechaud PD, Albrecht U, Mohammadi M, Dwyer A, Acierno JS Jr, Schoonjans K, Fajas L, Greub G, Pitteloud N. JCI Insight. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. 2017 Apr 20;2(8). pii: 91809. doi: 10.1172/jci.insight.91809. [Epub ahead of print]

42. Pellegrin M, Szostak J, Bouzourène K, Aubert JF, Berthelot A, Nussberger J, Laurant P, Mazzolai L. Running Exercise and Angiotensin II Type I Receptor Blocker Telmisartan Are Equally Effective in Preventing Angiotensin II-Mediated Vulnerable Atherosclerotic Lesions. J Cardiovasc Pharmacol Ther. 2016 May 30. pii: 1074248416652235. [Epub ahead of print]

41. Lavoie S., Steullet, P., Kulak A., Preitner F., Do K. Q. and Magistretti, P. J. Glutamate Cysteine Ligase—Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage. Front. Physiol., 21 April 2016 |

40. Minocha S, Sung TL, Villeneuve D, Lammers F, Herr W. Compensatory embryonic response to allele-specific inactivation of the murine X-linked gene Hcfc1. Dev Biol. 2016 Apr 1;412(1):1-17. doi: 10.1016/j.ydbio.2016.02.019. Epub 2016 Feb 24.

39. Emery M, Nanchen N, Preitner F, Ibberson M, Roduit R. Biological Characterization of Gene Response to Insulin-Induced Hypoglycemia in Mouse Retina. PLoS One. 2016 Feb 26;11(2):e0150266. doi: 10.1371/journal.pone.0150266.

38. Denechaud PD, Lopez-Mejia IC, Giralt A, Lai Q, Blanchet E, Delacuisine B, Nicolay BN, Dyson NJ, Bonner C, Pattou F, Annicotte JS, Fajas L. E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis. J Clin Invest. 2016 Jan;126(1):137-50. doi: 10.1172/JCI81542. Epub 2015 Nov 30.

37. Bernier-Latmani J, Cisarovsky C, Demir CS, Bruand M, Jaquet M, Davanture S, Ragusa S, Siegert S, Dormond O, Benedito R, Radtke F, Luther SA, Petrova DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. J Clin Invest. 2015 Nov 3;125(12):4572-86.

36. Parapanov R, Lugrin J, Rosenblatt-Velin N, Feihl F, Waeber B, Milano G, Vergely C, Li N, Pacher P, Liaudet L. Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse. Clin Sci (Lond). 2015 Jul;129(2):187-98. doi: 10.1042/CS20140444.

35. Bonhoure N, Byrnes A, Moir RD, Hodroj W, Preitner F, Praz V, Marcelin G, Chua SC Jr, Martinez-Lopez N, Singh R, Moullan N, Auwerx J, Willemin G, Shah H, Hartil K, Vaitheesvaran B, Kurland I, Hernandez N, Willis IM. Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Genes Dev. 2015 May 1;29(9):934-47. doi: 10.1101/gad.258350.115.

34. Montecucco F, Lenglet S, Carbone F, Boero S, Pelli G, Burger F, Roth A, Bertolotto M, Nencioni A, Cea M, Dallegri F, Fraga-Silva RA, Fougère L, Elfakir C, Gassner AL, Rudaz S, Parissaux X, Wils D, Salomé M, Vuilleumier N, Poggi A, Mach F. Treatment with KLEPTOSE® CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response. Vascul Pharmacol. 2015 Apr 25. pii: S1537-1891(15)00077-4. doi: 10.1016/j.vph.2015.04.008. [Epub ahead of print]

33. Wawrzyniak M, Pich C, Gross B, Schütz F, Fleury S, Quemener S, Sgandurra M, Bouchaert E, Moret C, Mury L, Rommens C, Mottaz H, Dombrowicz D, Michalik L. Endothelial, but not smooth muscle, peroxisome proliferator-activated receptor β/δ regulates vascular permeability and anaphylaxis. J Allergy Clin Immunol. 2015 Jun;135(6):1625-1635.e5. doi: 10.1016/j.jaci.2014.11.006. Epub 2014 Dec 31.

32. Fraga-Silva RA, Costa-Fraga FP, Montecucco F, Sturny M, Faye Y, Mach F, Pelli G, Shenoy V, da Silva RF, Raizada MK, Santos RA, Stergiopulos N. Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury. J Sex Med. 2015 Feb;12(2):289-302. doi: 10.1111/jsm.12757. Epub 2014 Nov 20.

31. Chalmin F, Rochemont V, Lippens C, Clottu A, Sailer AW, Merkler D, Hugues S, Pot C. Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity. J Autoimmun. 2015 Jan;56:45-55. doi: 10.1016/j.jaut.2014.10.001. Epub 2014 Nov 10.

30. Mang GM, Pradervand S, Du N-H, Preitner F, Wigger L, Gatfield D, Franken P. A neuron-specific deletion of the microRNA-processing enzyme DICER induces severe but transient obesity in mice. PLoS One. 2015 Jan 28;10(1):e0116760. doi: 10.1371/journal.pone.0116760. eCollection 2015.

29. Fraga-Silva RA, Savergnini SQ, Montecucco F, Nencioni A, Caffa I, Soncini D, Costa-Fraga FP, De Sousa FB, Sinisterra RD, Capettini LA, Lenglet S, Galan K, Pelli G, Bertolotto M, Pende A, Spinella G, Pane B, Dallegri F, Palombo D, Mach F, Stergiopulos N, Santos RA1, da Silva RF2. Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques. Thromb Haemost. 2014 Apr 1;111(4):736-47. doi: 10.1160/TH13-06-0448. Epub 2014 Feb 6.

28. Fraga-Silva RA, Costa-Fraga FP, Faye Y, Sturny M, Santos RA, da Silva RF, Stergiopulos N. An increased arginase activity is associated with corpus cavernosum impairment induced by hypercholesterolemia. J Sex Med. 2014 May;11(5):1173-81. doi: 10.1111/jsm.12482. Epub 2014 Feb 25.

27. Winnik S, Gaul DS, Preitner F, Lohmann C, Weber J, Miranda MX, Liu Y, van Tits LJ, Mateos JM, Brokopp CE, Auwerx J, Thorens B, Lüscher TF, Matter CM. Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development. Basic Res Cardiol. 2014 Jan;109(1):399. Epub 2013 Dec 27.

26. Lengacher S, Nehiri T, Preitner F, Stehle J-C, Dix L, Pralong F, Magistretti PJ and Pellerin L. Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 (MCT1) mice. PLoS One 2013 Dec 18;8(12):e82505.

25. Fraga-Silva RA, Costa-Fraga FP, Montecucco F, Faye Y, Savergnini SQ, Lenglet S, Mach F, Steffens S, Stergiopulos N, dos Santos RA, da Silva RF. Treatment with CB2 agonist JWH-133 reduces histological features associated with erectile dysfunction in hypercholesterolemic mice. Clin Dev Immunol. 2013;2013:263846. doi: 10.1155/2013/263846. Epub 2013 Nov 3.

24. Nencioni A, da Silva RF, Fraga-Silva RA, Steffens S, Fabre M, Bauer I, Caffa I, Magnone M, Sociali G, Quercioli A, Pelli G, Lenglet S, Galan K, Burger F, Vázquez Calvo S, Bertolotto M, Bruzzone S, Ballestrero A, Patrone F, Dallegri F, Santos RA, Stergiopulos N, Mach F, Vuilleumier N, Montecucco F2. Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice. Thromb Haemost. 2014 Feb;111(2):308-22. doi: 10.1160/TH13-07-0531. Epub 2013 Nov 7.

23. Ding J, Loizides-Mangold U, Rando G, Zoete V, Michielin O, Reddy JK, Wahli W, Riezman H, Thorens B. The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain fatty acids. Cell Rep. 2013 Oct 17;5(1):248-58. doi: 10.1016/j.celrep.2013.08.032.

22. Fraga-Silva RA, Costa-Fraga FP, Savergnini SQ, De Sousa FB, Montecucco F, da Silva D, Sinisterra RD, Mach F, Stergiopulos N, da Silva RF, Santos RA. An oral formulation of angiotensin-(1-7) reverses corpus cavernosum damages induced by hypercholesterolemia. J Sex Med. 2013 Oct;10(10):2430-42. doi: 10.1111/jsm.12262. Epub 2013 Jul 24.

21. Bonal CB, Baronnier DE, Pot C, Benkhoucha M, Schwab ME, Lalive PH, Herrera PL. Nogo-a downregulation improves insulin secretion in mice. Diabetes. 2013 May;62(5):1443-52.

20. Seyer P, Vallois D, Poitry-Yamate C, Schütz F, Metref S, Tarussio D, Maechler P, Staels B, Lanz B, Grueter R, Decaris J, Turner S, da Costa A, Preitner F, Minehira K, Foretz M, Thorens B. Hepatic glucose sensing is required to preserve β cell glucose competence. J Clin Invest. 2013 Apr 1;123(4):1662-76.

19. Willemin G, Roger C, Bauduret A, Minehira K. Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice. Int J Endocrinol. 2013;2013:972962. doi: 10.1155/2013/972962. Epub 2013 Apr 24.

18. Kostadinova R, Montagner A, Gouranton E, Fleury S, Guillou H, Dombrowicz D, Desreumaux P, Wahli W. GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation. Cell Biosci. 2012 Oct 10;2(1):34.

17. Hinard V, Mikhail C, Pradervand S, Curie T, Houtkooper RH, Auwerx J, Franken P, Tafti M. Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures. J Neurosci. 2012 Sep 5;32(36):12506-17.

16. Carvas JM, Vukolic A, Yepuri G, Xiong Y, Popp K, Schmutz I, Chappuis S, Albrecht U, Ming XF, Montani JP, Yang Z. Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis. Front Physiol. 2012;3:337. doi: 10.3389/fphys.2012.00337. Epub 2012 Aug 23.

15. Que YA, Delodder F, Guessous I, Graf R, Bain M, Calandra T, Liaudet L, Eggimann P. Pancreatic stone protein as an early biomarker predicting mortality in a prospective cohort of patients with sepsis requiring ICU management. Crit Care. 2012 Jul 2;16(4):R114. doi: 10.1186/cc11406.

14. Ming XF, Rajapakse AG, Yepuri G, Xiong Y, Carvas JM, Ruffieux J, Scerri I, Wu Z, Popp K, Li J, Sartori C, Scherrer U, Kwak BR, Montani JP, Yang Z. Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis. J Am Heart Assoc. 2012 Aug;1(4):e000992. doi:10.1161/JAHA.112.000992. Epub 2012 Aug 24.

13. Suarez PE, Rodriguez EG, Soundararajan R, Mérillat AM, Stehle JC, Rotman S, Roger T, Voirol MJ, Wang J, Gross O, Pétrilli V, Nadra K, Wilson A, Beermann F, Pralong FP, Maillard M, PearceD, Chrast R, Rossier BC, Hummler E. The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. Mol Endocrinol. 2012 Jun;26(6):1000-13.

12. Nadra K, Médard JJ, Mul JD, Han GS, Grès S, Pende M, Metzger D, Chambon P, Cuppen E, Saulnier-Blache JS, Carman GM, Desvergne B, Chrast R. Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Mol Cell Biol. 2012 Dec;32(23):4794-810.

11. Ye Q, Danzer CF, Fuchs A, Krek W, Mueggler T, Baltes C, Rudin M. Longitudinal evaluation of intramyocellular lipids (IMCLs) in tibialis anterior muscle of ob/ob and ob/+ control mice using a cryogenic surface coil at 9.4 T. NMR Biomed. 2011 Dec;24(10):1295-301.

10. Thorel F, Damond N, Chera S, Wiederkehr A, Thorens B, Meda P, Wollheim CB, Herrera PL. Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. Diabetes. 2011 Nov;60(11):2872-82.

9. Becattini B, Marone R, Zani F, Arsenijevic D, Seydoux J, Montani J-P, Dulloo A, Thorens B, Preitner F, Wymann M, Solinas, G. PI3Kγ within a Non-Hematopoietic Compartment Negatively Regulates Diet-Induced Thermogenesis, and is Key to Diet-Induced Obesity and Insulin Resistance. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):E854-63. Epub 2011 Sep 26

8. El Kochairi I, Montagner A, Rando G, Lohmann C, Matter CM, Wahli W. Beneficial effects of combinatorial micronutrition on body fat and atherosclerosis in mice. Cardiovasc Res. 2011 Sep 1;91(4):732-41.

7. Emery M, Schorderet DF, Roduit R. Acute hypoglycemia induces retinal cell death in mouse. PLoS One. 2011;6(6):e21586. Epub 2011 Jun 27.

6. Hegi ME, Diserens AC, Bady P, Kamoshima Y, Kouwenhoven MC, Delorenzi M, Lambiv WL, Hamou MF, Matter MS, Koch A, Heppner FL, Yonekawa Y, Merlo A, Frei K, Mariani L, Hofer S. Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib – A Phase II Trial. Mol Cancer Ther. 2011 Jun;10(6):1102-12. Epub 2011 Apr 6.

5. L. Mounien, N. Marty, D. Tarussio, S. Metref, D. Genoux, F. Preitner, M. Foretz, and B. Thorens. Glut2-dependent Glucose Sensing Controls Thermoregulation by Enhancing the Leptin Sensitivity of NPY and POMC Neurons. . FASEB Journal, 2010 Jun;24(6):1747-58. Epub 2010 Jan 22.

4. Silva JP, von Meyenn F, Howell J, Thorens B, Wolfrum C, Stoffel M. Regulation of adaptive behaviour during fasting by hypothalamic Foxa2. Nature. 2009 Dec 3;462(7273):646-50.

3. Le Martelot G, Claudel T, Gatfield D, Schaad O, Kornmann B, Lo Sasso G, Moschetta A, Schibler U. REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol. 2009 Sep;7(9):e1000181.

2. Minehira, K., Young, SG., Villanueva, CJ., Yetukuri, L., Oresic, M., Hellerstein, MK., Farese, RV. Jr, Horton, JD., Preitner, F., Thorens, B., and Tappy, L. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res. 49(9):2038-44, 2008

1. Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, BT., and Tschopp, J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science. 320 (5876):674-7, 2008