In this new paper, published in the Journal of Cell Biology, we show that the F-BAR protein Cdc15, a major component of the cytokinetic actomyosin contractile ring, is a direct substrate for Pom1 kinase. Phosphorylation by Pom1 blocks interaction of Cdc15 with several binding partners and destabilizes the ring, allowing it to slide if it assembles at the cell poles. Thus, Pom1 at cell poles protects these regions by blocking ring stabilization.
- New paper showing relocalization of Pom1 in response to glucose deprivation
- ERC Consolidator Grant to study cell-cell fusion