New lab publication in the Journal of Cell Science

Check our latest publication in the Journal of Cell Science. We show that ectopic localization of Tea4 on cell sides is sufficient to activate Cdc42 and promote growth at this location, yielding cells with a medial bulge. This activity depends on Tea4 binding a catalytic phosphatase 1 subunit, and indeed ectopic targeting of a catalytic subunit to the same location produces the same phenotype. This activity is further dependent on Gef1, a Cdc42 GEF, and Rga4, a Cdc42 GAP.