Check our latest publication at Cell Cycle. We show that two distinct levels of Pom1 control cell cycle timing and positioning: partial inhibition of Pom1 promotes faster mitotic entry, but has no effect on the position of the division plane at the cell middle. We further show that Pom1 phosphorylates the C-terminal tail of Cdr2 to negatively regulate its activity, independently of Cdr2 localization. We also show in this publication that Pom1 levels at the medial cortex do not substantially vary in cells of increasing sizes. This raises questions about where Pom1 inhibits Cdr2 activity, and whether Pom1 acts as cell size sensor.
- Libera Lo Presti receives Faculty Prize
- Sophie Martin receives Friedrich Miescher award