Working papers

R. M. Maier, Z. Zhihong, S. H. Lee, M. Trzaskowski, D. M. Ruderfer, E. A. Stahl, S. Ripke, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, N. R. Wray, J. Yang, P. M. Visscher, and M. R. Robinson, “Improving genetic prediction by leveraging genetic correlations among human diseases and traits.” Under review at Nature Communications. Software is released and in use https://github.com/uqrmaie1/smtpred

J. Zeng, R. de Vlaming, Y. Wu, M. R. Robinson, L. Lloyd-Jones, L. Yengo, C. Yap, A. Xue, J. Sidorenko, A. McRae, J. Powell, G. Montgomery, A. Metspalu, T. Esko, G. Gibson, N. Wray, P. Visscher, and J. Yang, “Widespread signatures of negative selection in the genetic architecture of human complex traits”. bioRxiv, p. 145755, 2017. Under review at Nature Genetics.

Q. Zhang, R. E. Marioni, M. R. Robinson, N. R. Wray, I. J. Deary, A. F. McRae and P. M. Visscher, “Genotype and genotype-by-age effects contribute to the variation of the human methylome in older people.” Under review at Genome Biology.

J. Guo, Y. Wu, Z. Zhu, Z. Zheng, M. Trzaskowski, M. R. Robinson, P. M. Visscher, J. Yang, “Global genetic differentiation of complex traits shaped by natural selection in humans”. Under review at Nature Communications.

J. J. Lee, R. Wedow, A. Okbay, E. Kong, O. Maghzian, M. Zacher, T. Anh Nguyen-Viet, P. Bowers, J. Sidorenko, R. Karlsson Linnér, M. A. Fontana, T. Kundu, C. Lee, H. Li, R. Li, R. Royer, P. Timshel, R. K. Walters, E. A. Willoughby, L. Yengo, 23andMe Research Team, Social Science Genetic Association Consortium, M. Alver, Y. Bao, D. W. Clark, F. R. Day, P. K. Joshi, K. E. Kemper, C. Langenberg, R. Mägi, J. W. Trampush, S. S. Verma, Y. Wu, M. L. Z. Yang, J. H. Zhao, Z. Zheng, J. D. Boardman, H. Campbell, J. Freese, K. M. Harris, C. Hayward, P. Herd, M. Kumari, T. Lencz, J. Luan, M. B. McQueen, A. Metspalu, L. Milani, K. K. Ong, J. R. Perry, D. J. Porteous, M. D. Ritchie, M. Smart, B. H. Smith, N. J. Wareham, J. F. Wilson, J. P. Beauchamp, D. Conley, T. Esko, S. F. Lehrer, P. K. E. Magnusson, S. Oskarsson, T. H. Pers, M. R. Robinson, K. Thom, C. Watson, C. F. Chabris, M. Johannesson, M. N. Meyer, D. I. Laibson, J. Yang, P. D. Koellinger, P. Turley, P. M. Visscher, D. J. Benjamin, and David Cesarini, “Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment”. Under review at Nature Genetics.

2017

Z. Zhu, Z. Zheng, F. Zhang, Y. Wu, M. Trzaskowski, R. Maier, M. R. Robinson, J. McGrath, P. Visscher, N. Wray, and J. Yang, “Causal associations between risk factors and common diseases inferred from GWAS summary data,” Nature Communications in press.

J. S. Sanjak, J. Sidorenko, M. R. Robinson, K. R. Thornton, and P. M. Visscher, “Evidence of directional and stabilizing selection in contemporary humans,” PNAS in press

D. Burger, S. Thomas, H. Aepli, M. Dreyer, G. Fabre, E. Marti, H. Sieme, M. R. Robinson, C. Wedekind, “MHC-linked social signalling affects female fertility,” Proc. R. Soc. B in press

J. C. Reger, M. Lind, M. R. Robinson and A. Beckerman, “Predation drives local adaptation of phenotypic plasticity” Nature Ecology and Evolution in press

F. C. Tropf, S. H. Lee, R. M. Verweij, G. Stulp, P. J. van der Most, R. de Vlaming, A. Bakshi, D. A. Briley, C. Rahal, R. Hellpap, A. N. Iliadou, T. Esko, A. Metspalu, S. E. Medland, N. G. Martin, N. Barban, H. Snieder, M. R. Robinson, and M. C. Mills, “Hidden heritability due to heterogeneity across seven populations,” Nature Human Behaviour, p. 1, 2017.

M. R. Robinson, G. English, G. Moser, L. R. Lloyd-Jones, M. A. Triplett, Z. Zhu, I. M. Nolte, J. V van Vliet-Ostaptchouk, H. Snieder, T. Esko, L. Milani, R. Mägi, A. Metspalu, P. K. E. Magnusson, N. L. Pedersen, E. Ingelsson, M. Johannesson, J. Yang, D. Cesarini, and P. M. Visscher, “Genotype–covariate interaction effects and the heritability of adult body mass index,” Nature Genetics, vol. 49, no. 8, pp. 1174–1181, 2017.

M. R. Robinson, A. Kleinman, M. Graff, A. A. E. Vinkhuyzen, D. Couper, M. B. Miller, W. J. Peyrot, A. Abdellaoui, B. P. Zietsch, I. M. Nolte, J. V. van Vliet-Ostaptchouk, H. Snieder, The LifeLines Consortium, The Genetic Investigation of ANthropometric Traits (GIANT) consortium, S. E. Medland, N. G. Martin, P. K. E. Magnusson, W. G. Iacono, M. McGue, K. E. North, J. Yang, and P. M. Visscher, “Genetic evidence of assortative mating in humans,” Nature Human Behaviour, vol. 1, no. 1, p. 16, 2017.

L. Yengo, Z. Zhu, N. R. Wray, B. S. Weir, J. Yang, M. R. Robinson, and P. M. Visscher, “Detection and quantification of inbreeding depression for complex traits from SNP data,” Proceedings of the National Academy of Sciences, vol. 114, no. 32, p. 201621096, 2017.

R. M. Maier, P. M. Visscher, M. R. Robinson, and N. R. Wray, “Embracing polygenicity: a review of methods and tools for psychiatric genetics research,” Psychological Medicine, pp. 1–19, 2017.

F. C. Garton, B. Benyamin, Q. Zhao, Z. Liu, J. Gratten, A. K. Henders, Z.-H. Zhang, J. Edson, S. Furlong, S. Morgan, S. Heggie, K. Thorpe, C. Pfluger, K. A. Mather, P. S. Sachdev, A. F. McRae, M. R. Robinson, S. Shah, P. M. Visscher, M. Mangelsdorf, R. D. Henderson, N. R. Wray, and P. A. McCombe, “Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort,” Molecular Genetics & Genomic Medicine, vol. 5, no. 4, pp. 418–428, 2017.

L. R. Lloyd-Jones, M. R. Robinson, G. Moser, J. Zeng, S. Beleza, G. S. Barsh, H. Tang, and P. M. Visscher, “Inference on the Genetic Basis of Eye and Skin Color in an Admixed Population via Bayesian Linear Mixed Models,” Genetics, vol. 206, no. 2, pp. 1113–1126, 2017.

 

2016

G.-B. Chen, S. H. Lee, Z.-X. Zhu, B. Benyamin, and M. R. Robinson, “EigenGWAS: finding loci under selection through genome-wide association studies of eigenvectors in structured populations,” Heredity, vol. 117, no. 1, pp. 51–61, 2016.

W. van Rheenen, A. Shatunov, A. M. Dekker, R. L. McLaughlin, F. P. Diekstra, S. L. Pulit, R. A. A. van der Spek, U. Võsa, S. de Jong, M. R. Robinson, et al., “Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis,” Nature Genetics, vol. 48, no. 9, pp. 1043–1048, 2016.

Z. Zhu, F. Zhang, H. Hu, A. Bakshi, M. R. Robinson, J. E. Powell, G. W. Montgomery, M. E. Goddard, N. R. Wray, P. M. Visscher, and J. Yang, “Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets,” Nature Genetics, vol. 48, no. 5, pp. 481–487, 2016.

W. J. Peyrot, M. R. Robinson, B. W. J. H. Penninx, and N. R. Wray, “Exploring Boundaries for the Genetic Consequences of Assortative Mating for Psychiatric Traits,” JAMA Psychiatry, vol. 73, no. 11, p. 1189, 2016.

G.-B. Chen, S. H. Lee, M. R. Robinson, M. Trzaskowski, Z.-X. Zhu, T. W. Winkler, F. R. Day, D. C. Croteau-Chonka, A. R. Wood, A. E. Locke, Z. Kutalik, R. J. F. Loos, T. M. Frayling, J. N. Hirschhorn, J. Yang, N. R. Wray, and P. M. Visscher, “Across-cohort QC analyses of GWAS summary statistics from complex traits,” European Journal of Human Genetics, vol. 25, no. 1, pp. 137–146, 2016.

2015

M. R. Robinson, G. Hemani, C. Medina-Gomez, M. Mezzavilla, T. Esko, K. Shakhbazov, J. E. Powell, A. Vinkhuyzen, S. I. Berndt, S. Gustafsson, A. E. Justice, B. Kahali, A. E. Locke, T. H. Pers, S. Vedantam, A. R. Wood, W. van Rheenen, O. A. Andreassen, P. Gasparini, A. Metspalu, L. H. van den Berg, J. H. Veldink, F. Rivadeneira, T. M. Werge, G. R. Abecasis, D. I. Boomsma, D. I. Chasman, E. J. C. de Geus, T. M. Frayling, J. N. Hirschhorn, J. J. Hottenga, E. Ingelsson, R. J. F. Loos, P. K. E. Magnusson, N. G. Martin, G. W. Montgomery, K. E. North, N. L. Pedersen, T. D. Spector, E. K. Speliotes, M. E. Goddard, J. Yang, and P. M. Visscher, “Population genetic differentiation of height and body mass index across Europe.,” Nature genetics, vol. 47, no. 11, pp. 1357–62, 2015.

J. Yang, A. Bakshi, Z. Zhu, G. Hemani, A. A. E. Vinkhuyzen, S. H. Lee, M. R. Robinson, J. R. B. Perry, I. M. Nolte, J. V van Vliet-Ostaptchouk, H. Snieder, T. Esko, L. Milani, R. Mägi, A. Metspalu, A. Hamsten, P. K. E. Magnusson, N. L. Pedersen, E. Ingelsson, N. Soranzo, M. C. Keller, N. R. Wray, M. E. Goddard, and P. M. Visscher, “Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index,” Nature Genetics, vol. 47, no. 10, pp. 1114–1120, 2015.

A. W. Santure, J. Poissant, I. De Cauwer, K. Oers, M. R. Robinson, J. L. Quinn, M. A. M. Groenen, M. E. Visser, B. C. Sheldon, and J. Slate, “Replicated analysis of the genetic architecture of quantitative traits in two wild great tit populations,” Molecular ecology, vol. 24, no. 24, pp. 6148–6162, 2015.

M. J. Adams, M. R. Robinson, M. Mannarelli, and B. J. Hatchwell, “Social genetic and social environment effects on parental and helper care in a cooperatively breeding bird,” in Proceedings of the Royal Society B: Biological Sciences, 2015, vol. 282, no. 1810, p. 20150689.

​2014 and before

M. R. Robinson, N. R. Wray, and P. M. Visscher, “Explaining additional genetic variation in complex traits.,” Trends in genetics : TIG, vol. 30, no. 4, pp. 124–132, 2014.

M. R. Robinson and A. Qvarnström, “Influence of the Environment on the Genetic Architecture of Traits Involved in Sexual Selection within Wild Populations,” Genotype-by-Environment Interactions and Sexual Selection, pp. 137–168, 2014.

C. Teplitsky, M. R. Robinson, and J. Merilä, “Evolutionary potential and constraints in wild populations,” Quantitative genetics in the wild, pp. 190–208, 2014.

M. R. Robinson and A. P. Beckerman, “Quantifying multivariate plasticity: Genetic variation in resource acquisition drives plasticity in resource allocation to components of life history,” Ecology Letters, vol. 16, no. 3, pp. 281–290, 2013.

M. R. Robinson, A. W. Santure, I. Decauwer, B. C. Sheldon, and J. Slate, “Partitioning of genetic variation across the genome using multimarker methods in a wild bird population.,” Molecular ecology, vol. 22, no. 15, pp. 3963–80, 2013.

A. W. Santure, I. De Cauwer, M. R. Robinson, J. Poissant, B. C. Sheldon, and J. Slate, “Genomic dissection of variation in clutch size and egg mass in a wild great tit (Parus major) population,” Molecular Ecology, vol. 22, no. 15, pp. 3949–3962, 2013.

M. Adams, M. R. Robinson, and B. Hatchwell, “Their genes are your environment: Social genetics of breeding behavior in birds,” in BEHAVIOR GENETICS, 2013, vol. 43, no. 6, p. 505.

Robinson, M.R., Van Doorn, G., Gustafsson, L. & Qvarnström, A. (2012) Environment-dependent selection on mate choice in a natural population of birds. Ecology Letters 15, 611-618.

Robinson, M.R., U Mar, K. & Lummaa, V. (2012) Senescence and age-specific trade-offs between reproduction and survival in female Asian elephants. Ecology Letters, 15, 260-266.

Robinson, M.R. (2011) Understanding intrasexual competition and sexual selection requires an evolutionary ecology framework. Behavioural Ecology, 22, 1143-1144.

Robinson, M.R., Pilkington, J.G., Clutton-Brock, T.H., Pemberton, J.M. & Kruuk, L.E.B. (2009). The impact of early environmental heterogeneity on genetic architecture in a wild population of Soay sheep. Genetics 181, 1639-1648.

Robinson, M.R., Pilkington, J.G., Clutton-Brock, T.H., Pemberton, J.M. & Kruuk, L.E.B. (2008). Environmental heterogeneity generates fluctuating selection on a secondary sexual trait. Current Biology 18, 1-7.

Robinson, M.R., & Kruuk, L.E.B. (2007). Function of weaponry in females: the use of horns in intra-sexual competition for resources in female Soay sheep. Biology Letters 3, 651-654.

Robinson, M.R., Pilkington, J.G., Clutton-Brock, T.H., Pemberton, J.M. & Kruuk, L.E.B. (2006). Live fast, die young: Trade-offs between fitness components and sexually antagonistic selection, on weaponry in Soay sheep. Evolution, 60, 2168- 2181.