Meeting Program

Thursday, October 6, 2016:

12:00 PM-2:30 PM: Meeting registration

2:30-2:45 PM Welcome/Introductory remarks: Dario Diviani and Enno Klussmann, Meeting Chairs

Keynote opening lectures 2:45-4:15 PM

Chair: Dario Diviani

2:45-3:30 PM J. D. Scott (University of Washington, Howard Hugues Medical Institute) “Guiding Signals through anchored enzyme complexes”
3:30-4:15 PM M. von Zastrow (University of California, San Francisco) “The inner life of GPCRs”
4:15-4:45 AM Coffee break
Session 1: Compartmentalization of cAMP synthesis and degradation 4:45-6:45 PM

Chair: Enno Klussmann

4:45-5:15 PM C. Steegborn (University of Bayreuth) “Soluble adeniyly cyclase as an intracellular cAMP source: Function, regulation, structure and drugs”
5:15-5:45 PM G. Baillie (University of Glasgow) “Disruption of the HSP20 signalosome as a therapeutic strategy for cardiovascular diseses”.
5:45- 6:15 PM M. Movsesian (University of Utah) “Unique localisation and function of PDE3 isoforms in cardiac muscle”.
6:15-6:30 PM J. Buck (Weill Cornell Medical College) “A novel intracellular micro domain regulated by soluble adenylyl cyclase”
6:30-6:45 PM E. Stefan (University of Innsbruck) “Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling”
7:30PM: Welcome drink8:00PM: Dinner

Friday October 7, 2016:

Session 2: Structure-function of cAMP effectors 8:15- 10:30 AM

Chair: K. Tasken

8:15-9:00 AM S. Taylor (University Of California, San Diego, Howard Hugues Medical Institute) “Isoform-specific Targeting of PKA”
9:00-9:30 AM F. Herberg (Univesity of Kassel) “Affinity and Specificity of AKAP Scaffolding Interactions”.
9:30- 10:00 AM H. Rehmann (University Medical Center Utrecht) “Modulation of Epac1 and Epac2 signalling by selective cAMP-analogues”.
10:00-10:30 AM Eyers (University of Liverpool) “Analysis of PKA signalling complexes”
10:30-10:45 AM O. Rocks (Max-Delbrueck-Center for Molecular Medicine) “Bimodal antagonism of PKA signalling by ARHGAP36”
10:45-11:15 AM Coffee break
Session 3: Emerging roles of AKAPs in cardiac pathophysiology 11:15 -1:15 PM
11:15-11:45 AM D. Diviani (University of Lausanne) “The role of A kinase anchoring proteins in cardiac protection”
11:45-12:15 PM M. Kapiloff (University of Miami) “Regulation of Concentric Myocyte Hypertrophy by mAKAPβ Signalosomes”
12:15-12:45 PM K. Tasken (University of Oslo) “Targeting the adrenergic regulation of the SERCA2 complex in the heart with small molecules displacing the anchored kinase from its substrate protects from ischemia-reperfusion injury”.
12:45-1:00 PM T. Brand (Imperial College London) “A recessive mutation of the cAMP effector POPDC1 causes muscular dystrophy and cardiac arrhythmias by affecting protein trafficking”
1:00-1:15 PM G. Pidoux (INSERM-S1180, Paris) “Spatiotemporal regulation of connexin43 gap junction communication in the heart”
1:15-2:15 PM Lunch
2:15-4:15 PM Poster session
4:15- 4:45 PM coffee break
Session 4: Compartmentalized cAMP signaling in the vascular system 4:45-6:30 PM

Chair: R. Fischmeister

4:45-5:15 PM F. Santana (University of California, Davis) “Local Control of Smooth Muscle Excitability by AKAP150”
5:15-5:45 PM M. Navedo (University of California, Davis) “AKAP150 signalosome in vascular smooth muscle”
5:45-6:00 PM P. Nedvetsky (Vesalius research center, VIBKULeuven) “Role of endothelial PKA in vascular development”
6:00-6:15 PM




B.Grove (University of North Dakota) “Role of gravin/AKAP12 in vascular endothelial cell migration and angiogenesis”


B.Manoury (University Paris-Sud) “BK(Ca) channels are key effectors of coronary tone regulation by PDE3 and PDE4, but not in the failing heart”

7:30 PM: Dinner

Saturday, October 8, 2016:

Session 5: Compartmentalized cAMP signaling in the cardiac system 8:30-10:30 AM

Chair: F. Santana

8:30-9:00 AM R. Fischmeister (University Paris-Sud) “Differential regulation of cytoplasmic and nuclear PKA activities by β-adrenergic receptors in adult cardiac myocytes“
9:00-9:30 AM M. Zaccolo (University of Oxford) “Nanodomains of cAMP dictate fine tuning of cardiac contractility”
9:30-10:00 AM V. Nikolaev (University of Hamburg) “cAMP and PDE compartmentation in cardiac disease”
10:00-10:15 AM N.Musheshe (University of Oxford) “cAMP-mediated regulation of the cardiac phospholemman- Na+/K+ ATPase complex”
10:15-10:45 AM Coffee break
Session 6: Compartmentalized cAMP signaling in the nervous system 10:45 AM- 1:00 PM

Chair: John Scott

10:45-11:15 AM M. Dell’Acqua (University of Colorado, Denver) “Regulation of Neuronal Synaptic Plasticity by Anchored Kinase and Phosphatase Signaling”
11:15-11:45 AM T. Abel (University of Pennsylvania) “Anchored cAMP signaling mediates the impact of sleep deprivation on memory storage”
11:45-12:15 PM G. S. McKnight (University of Washington) “Regulation of neuronal circuits by PKA/AKAP complexes”
12:15-12:30 PM J. Zhang (University of California, San Diego) “AKAP-mediated PKA activity microdomains in living cells”
12:30-12:45 PM


12:45-1:00 PM

R. Ilouz (University of California San Diego)”Subcellular localization and functional characterization of cAMP-dependent protein kinase A isoforms : painting specificity by mosaic brain mapping ”

M. Gold (University College London) “AKAP79 regulation by Ca2+/calmodulin: structure and function

1:00-2:00 PM Lunch
2:00 PM-4:00 PM Poster session
4:00-4:30 PM coffee break
Session 7: AKAP-based signaling complexes and pharmacological targeting 4:30-6:30PM

Chair: S. Taylor

4:30- 5:00 PM E. Klussmann (Max-Delbrueck-Center for Molecular Medicine) “New options for targeting AKAP-PKA interactions and functions of the AKAP GSKIP”
5:00-5:30 PM E. Hirsch (University of Torino) “Targeting PI3Kg AKAP function to treat asthma and cystic fibrosis”
5:30-6:00 PM E. Kennedy (University of Georgia) “Targeting AKAP Complexes Using Constrained Peptide Scaffolds”
6:00-6:15 PM M. Schmidt (University of Groningen) “Targeting Epac-AKAP complexes to treat chronic inflammatory disorders”
6:15-6:30 PM D. Smith (University of Washington) “Local protein kinase A signaling proceeds through intact holoezyme complexes”
6:30- 6:45 PM Closing Remarks
7:30 PM Dinner

Sunday, October 9, 2016: